Maternal and foetal outcomes in pregnant patients with active lupus nephritis.
Maternal and foetal outcomes in pregnant patients with active lupus nephritis.
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活性狼疮肾炎患者的孕妇和胎儿结局。
DOI：
10.1177/0961203308097575
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发表时间：
2009-04
期刊：
影响因子：
2.6
通讯作者：
Garovic VD
中科院分区：
文献类型：
--
作者：
Wagner SJ;Craici I;Reed D;Norby S;Bailey K;Wiste HJ;Wood CM;Moder KG;Liang KP;Liang KV;Rose C;Rozkos T;Sitina M;Grande JP;Garovic VD
The objective of this study was to determine the impact of lupus nephritis disease activity on maternal and fetal outcomes in pregnant patients with systemic lupus erythematosus (SLE). Medical records of all pregnant patients with SLE treated at our institution between 1976 and 2007 were reviewed. All patients met American College of Rheumatology classification criteria for SLE. Demographic data, history of lupus nephritis, nephritis disease activity, and maternal and fetal outcomes of pregnancy were abstracted. Active lupus nephritis was defined as the presence of proteinuria > 0.5 g/day and/or active urinary sediment with or without an elevation in serum creatinine (Cr). Quiescent lupus nephritis was confirmed in the presence of proteinuria < 0.5 mg/day and inactive urinary sediment. We identified fifty-eight patients with ninety pregnancies. Compared to pregnancies in SLE patients without renal involvement (n=47), pregnancies in patients with active lupus nephritis (n=23) were associated with a higher incidence of maternal complications (57% vs. 11%, p<0.001), whereas those with quiescent lupus nephritis (n=20) were not (35% vs. 11%, p=0.10). Women with active lupus nephritis were more likely to deliver preterm than women without lupus nephritis, median of 34 weeks vs. 40 gestational weeks, respectively (p=0.002), and were more likely to suffer fetal loss (35% vs 9%, p=0.031). Active, but not quiescent, lupus nephritis during pregnancy is associated with a higher incidence of maternal and fetal complications compared to pregnancies in SLE patients without renal involvement.
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影响因子：
3.4
作者：
Cavallasca, Javier A.;Laborde, Hugo A.;Nasswetter, Gustavo G.
通讯作者：
Nasswetter, Gustavo G.
影响因子：
2.6
作者：
DERKSEN, RHWM;BRUINSE, HW;KATER, L
通讯作者：
KATER, L
影响因子：
2.6
作者：
JULKUNEN, H;JOUHIKAINEN, T;FRIMAN, C
通讯作者：
FRIMAN, C
影响因子：
2.6
作者：
Rahman, Farooq Z.;Rahman, Jessica;Rahman, M. Sayedur
通讯作者：
Rahman, M. Sayedur
影响因子：
27.4
作者：
Huong, DLT;Wechsler, B;Piette, JC
通讯作者：
Piette, JC