Sparse and skew hashing of K-mers.

Sparse and skew hashing of K-mers.
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DOI:
10.1093/bioinformatics/btac245
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发表时间:
2022-06-24
期刊:
Bioinformatics (Oxford, England)
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k-mers字典是一种存储n个不同k-mers的数据结构,并支持成员查询。这种数据结构是计算生物学中许多重要任务的核心。DNA的高通量测序可以产生非常大的k-mer集,大小可达数十亿个字符串——在这种情况下,数据结构的内存消耗和查询效率是一个具体的挑战。为了解决这个问题,我们为k-mers描述了一个压缩的关联字典,即:一个数据结构,其中字符串以紧凑的形式表示,并且每个字符串都与范围内的唯一整数标识符相关联。我们表明,与最著名的解决方案相比,k-mer最小化器的一些统计特性可以通过最小完美哈希来充分利用,从而大大改善字典的空间/时间权衡。https://github.com/jermp/sshash。补充数据可在生物信息学网站获得。
A dictionary of k-mers is a data structure that stores a set of n distinct k-mers and supports membership queries. This data structure is at the hearth of many important tasks in computational biology. High-throughput sequencing of DNA can produce very large k-mer sets, in the size of billions of strings—in such cases, the memory consumption and query efficiency of the data structure is a concrete challenge. To tackle this problem, we describe a compressed and associative dictionary for k-mers, that is: a data structure where strings are represented in compact form and each of them is associated to a unique integer identifier in the range . We show that some statistical properties of k-mer minimizers can be exploited by minimal perfect hashing to substantially improve the space/time trade-off of the dictionary compared to the best-known solutions. https://github.com/jermp/sshash. Supplementary data are available at Bioinformatics online.
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