Cytokine profile and ST-elevation myocardial infarction.
Cytokine profile and ST-elevation myocardial infarction.
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细胞因子谱和 ST 段抬高型心肌梗死。
DOI：
10.1161/circresaha.112.279380
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发表时间：
2012
影响因子：
20.1
通讯作者：
Perin,EmersonC
中科院分区：
文献类型：
--
作者：
Willerson,JamesT;Yeh,EdwardTH;Perin,EmersonC
在这一期的Circulation Research中，Ammirati等1获得了109例st段抬高型心肌梗死（STEMI）患者的数据，其中白细胞介素(IL)-6水平最高，与96例IL -6水平最低的患者进行了比较，以确定相互作用细胞因子水平的差异，从而可能预测临床结果。他们根据患者的循环细胞因子水平确定了两种不同的患者模块。其中一个模块包括与IL6(−)IL10 (+) STEMI患者相比，IL6 (+) IL10（+）升高，出院时收缩功能障碍加重，6个月死亡的STEMI患者。结合从两种鉴定的细胞因子模块中提取的IL10和IL6，提供了一种称为“ac指数”的风险指数-细胞因子联合指数，在预测收缩功能障碍和死亡方面优于任何单一细胞因子。作者得出结论，IL6和IL10水平同时升高将STEMI患者与其他STEMI患者区分为临床预后较差的患者。他们认为，这一信息可能对风险导向分层和免疫调节疗法具有潜在的临床意义。
In this issue of Circulation Research, Ammirati et al 1 have obtained data from 109 patients with ST-elevation myocardial infarction (STEMI) with the highest interleukin (IL)-6 levels compared with 96 patients with the lowest IL6 levels to identify differences in interacting cytokine levels that might predict clinical outcomes. They identified 2 different modules of patients from their circulating cytokine levels. One module included STEMI patients with increases in IL6 (+) IL10 (+), greater systolic dysfunction at discharge, and death at 6 months compared with IL6 (−) IL10 (+) STEMI patients. Combining IL10 with IL6 derived from the 2 identified cytokine modules provided a risk index combined-cytokine-index called the “AC-Index” that outperformed any single cytokine in the prediction of systolic dysfunction and death. The authors concluded that simultaneous elevation of IL6 and IL10 levels distinguishes STEMI patients with poorer clinical outcomes from other STEMI patients. They suggest that this information may have potential clinical implications for risk-oriented stratification and for immune-moderating therapies.
影响因子：
37.8
作者：
Ridker, PM;Rifai, N;Hennekens, CH
通讯作者：
Hennekens, CH
血浆白细胞介素6浓度及白细胞介素6基因-174G>C和-572G>C启动子多态性对溶栓治疗的急性心肌梗死患者的预后价值。
影响因子：
5.3
作者：
M. Bennermo;C. Held;F. Green;L. Strandberg;C. Ericsson;L. Hansson;H. Watkins;A. Hamsten;P. Tornvall
通讯作者：
P. Tornvall