Endothelial cell proliferation follows the mid-cycle luteinizing hormone surge, but not human chorionic gonadotrophin rescue, in the human corpus luteum.
Endothelial cell proliferation follows the mid-cycle luteinizing hormone surge, but not human chorionic gonadotrophin rescue, in the human corpus luteum.
复制标题
在人黄体中，内皮细胞增殖跟随中期黄体生成激素激增，但不跟随人绒毛膜促性腺激素的拯救。
作者：
F. E. Rodger;F. Young;H. M. Fraser;P. Illingworth
黄体对维持妇女早期妊娠至关重要。血管新生可能是黄体抢救的一个因素。本研究的目的是确定整个黄体期内皮细胞增殖的变化和人绒毛膜促性腺激素（HCG）模拟早期妊娠。在整个黄体期和模拟妊娠早期获得的人黄体用内皮细胞和增殖细胞抗体进行免疫染色。观察内皮细胞和增殖细胞的数量和分布。内皮细胞数量在黄体前期最少，在黄体中期增加（P < 0.03）。内皮细胞数量在晚期和抢救后的黄体之间没有显著差异。内皮细胞增殖在黄体早期最大，在后期继续保持较低水平。模拟早孕对内皮细胞增殖无影响。这些结果表明，内皮细胞的高度增殖与人黄体的形成有关。HCG治疗后增殖水平不变（排卵后第12天至第16天5-8天，剂量为125 IU至16000 IU，每日剂量加倍）表明黄体抢救过程涉及其他过程。
The corpus luteum is essential for the maintenance of early pregnancy in women. Angiogenesis may be one factor involved in luteal rescue. The aim of this study was to determine the changes in endothelial cell proliferation throughout the luteal phase and in human chorionic gonadotrophin (HCG)-simulated early pregnancy. Human corpora lutea obtained throughout the luteal phase and in simulated early pregnancy were immunostained with antibodies for endothelial and proliferating cells. Number and distribution of endothelial and proliferating cells were examined. Endothelial cells were least abundant in the early luteal phase, increasing in the mid-luteal phase (P < 0.03). Endothelial numbers did not differ significantly between the late and the rescued corpora lutea. Endothelial cell proliferation was greatest in the early luteal phase and continued at a lower level during later stages. Simulated early pregnancy resulted in no change in endothelial cell proliferation. These results showed that a high degree of endothelial cell proliferation is associated with formation of the human corpus luteum. Unchanging levels of proliferation following HCG treatment (for 5-8 days from day 12 to day 16 post-ovulation, at 125 IU to 16,000 IU, following a daily doubling of dose) suggest that alternative processes are involved during luteal rescue.
DOI：
10.1530/jrf.0.0840513
发表时间：
1988-11
期刊：
Journal of reproduction and fertility
影响因子：
--
作者：
M. C. Wiltbank;R. Dysko;K. P. Gallagher;P. Keyes
通讯作者：
M. C. Wiltbank;R. Dysko;K. P. Gallagher;P. Keyes
DOI：
--
发表时间：
2007
期刊：
--
影响因子：
--
作者：
B. Kamat;L. Brown;E. Manseau;D. Senger;H. Dvorak
通讯作者：
B. Kamat;L. Brown;E. Manseau;D. Senger;H. Dvorak