Disparities in breast cancer outcomes between Caucasian and African American women: a model for describing the relationship of biological and nonbiological factors.
Disparities in breast cancer outcomes between Caucasian and African American women: a model for describing the relationship of biological and nonbiological factors.
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DOI：
10.1186/bcr3429
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发表时间：
2013-06-27
期刊：
影响因子：
--
通讯作者：
Danforth DN Jr
中科院分区：
文献类型：
--
作者：
Danforth DN Jr
乳腺癌是美国女性中最常见的恶性肿瘤，但与白人女性相比，非洲裔美国女性存在显著差异。非裔美国女性患乳腺癌的年龄更小，50岁以下的发病率更高，在组织学上发展为更具侵袭性的肿瘤，在发病时处于更晚期，并且无病生存率和总体生存率比白人女性更差。原发肿瘤的生物学特性在决定差异的结果中起着重要作用，非洲裔美国人和高加索人乳腺癌在类固醇受体和生长因子受体含量、细胞周期成分突变、染色体异常、肿瘤抑制基因和其他癌症基因方面存在显著差异。生物因素的后果受到多种非生物因素的影响，包括社会经济、医疗保健、生殖和混杂因素。非生物因素可能直接增强（或抑制）生物变化的后果，间接促进差异的结果，或作为共同因素推动生物因素与差异之间的关联。预防和管理这种差异需要了解生物和非生物因素之间的关系。本综述旨在通过描述四种主要差异的生物学基础——发病年龄早、疾病进展较晚、组织学变化更剧烈、生存率更差——以及与非生物学因素的重要关系来促进这一认识。提出了一个模型，以提供对这种关系的全面看法，其目标是促进对每种差异的理解以及消除差异需要解决的问题。
Breast cancer is the most common malignancy in women in the United States but significant disparities exist for African American women compared to Caucasian women. African American women present with breast cancer at a younger age and with a greater incidence under the age of 50 years, develop histologically more aggressive tumors that are at a more advanced stage at presentation, and have a worse disease-free and overall survival than Caucasian women. The biological characteristics of the primary tumor play an important role in determining the outcome of the disparity, and significant differences have been identified between African American and Caucasian breast cancer in steroid receptor and growth factor receptor content, mutations in cell cycle components, chromosomal abnormalities, and tumor suppressor and other cancer genes. The consequences of the biological factors are influenced by a variety of nonbiological factors, including socioeconomic, health care access, reproductive, and confounding factors. The nonbiological factors may act directly to enhance (or inhibit) the consequences of the biological changes, indirectly to facilitate outcome of the disparity, or as a cofounding factor, driving the association between the biological factors and the disparity. The prevention and management of the disparities will require an understanding of the relationship of biological and nonbiological factors. The present review was undertaken to promote this understanding by describing the biological basis of the four major disparities - early age of onset, more advanced stage of disease, more aggressive histologic changes, and worse survival - and the important relationship to the nonbiological factors. A model is proposed to provide a comprehensive view of this relationship, with the goal of facilitating an understanding of each disparity and the issues that need to be addressed to eliminate the disparity.
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影响因子：
11.5
作者：
Azim, Hatem A., Jr.;Michiels, Stefan;Loi, Sherene
通讯作者：
Loi, Sherene
DOI：
10.1158/1078-0432.ccr-08-3293
发表时间：
2009-06-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Agarwal R;Gonzalez-Angulo AM;Myhre S;Carey M;Lee JS;Overgaard J;Alsner J;Stemke-Hale K;Lluch A;Neve RM;Kuo WL;Sorlie T;Sahin A;Valero V;Keyomarsi K;Gray JW;Borresen-Dale AL;Mills GB;Hennessy BT
通讯作者：
Hennessy BT
影响因子：
8.8
作者：
Aaltonen, K.;Amini, R-M;Heikkila, P.;Aittomaki, K.;Tamminen, A.;Nevanlinna, H.;Blomqvist, C.
通讯作者：
Blomqvist, C.
激素受体状态，肿瘤特征和预后：乳腺癌患者的前瞻性队列。
DOI：
10.1186/bcr1639
发表时间：
2007
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Dunnwald LK;Rossing MA;Li CI
通讯作者：
Li CI
影响因子：
105.7
作者：
BRUZZI, P;NEGRI, E;DELTURCO, MR
通讯作者：
DELTURCO, MR