Neuroimaging of Mouse Models of Alzheimer's Disease.
Neuroimaging of Mouse Models of Alzheimer's Disease.
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DOI：
10.3390/biomedicines10020305
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发表时间：
2022-01-28
期刊：
影响因子：
4.7
通讯作者：
Obenaus A
中科院分区：
文献类型：
--
作者：
Jullienne A;Trinh MV;Obenaus A
Magnetic resonance imaging (MRI) and positron emission tomography (PET) have made great strides in the diagnosis and our understanding of Alzheimer’s Disease (AD). Despite the knowledge gained from human studies, mouse models have and continue to play an important role in deciphering the cellular and molecular evolution of AD. MRI and PET are now being increasingly used to investigate neuroimaging features in mouse models and provide the basis for rapid translation to the clinical setting. Here, we provide an overview of the human MRI and PET imaging landscape as a prelude to an in-depth review of preclinical imaging in mice. A broad range of mouse models recapitulate certain aspects of the human AD, but no single model simulates the human disease spectrum. We focused on the two of the most popular mouse models, the 3xTg-AD and the 5xFAD models, and we summarized all known published MRI and PET imaging data, including contrasting findings. The goal of this review is to provide the reader with broad framework to guide future studies in existing and future mouse models of AD. We also highlight aspects of MRI and PET imaging that could be improved to increase rigor and reproducibility in future imaging studies.
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影响因子：
2.9
作者：
Carreras, Isabel;McKee, Ann C.;Dedeoglu, Alpaslan
通讯作者：
Dedeoglu, Alpaslan
影响因子：
5.7
作者：
Badea A;Kane L;Anderson RJ;Qi Y;Foster M;Cofer GP;Medvitz N;Buckley AF;Badea AK;Wetsel WC;Colton CA
通讯作者：
Colton CA
DOI：
10.1007/s00259-021-05253-y
发表时间：
2021-07
影响因子：
9.1
作者：
Ashton NJ;Leuzy A;Karikari TK;Mattsson-Carlgren N;Dodich A;Boccardi M;Corre J;Drzezga A;Nordberg A;Ossenkoppele R;Zetterberg H;Blennow K;Frisoni GB;Garibotto V;Hansson O
通讯作者：
Hansson O
影响因子：
--
作者：
Baek H;Ye M;Kang GH;Lee C;Lee G;Choi DB;Jung J;Kim H;Lee S;Kim JS;Lee HJ;Shim I;Lee JH;Bae H
通讯作者：
Bae H
影响因子：
2.9
作者：
Chang, Suk-Ki;Kim, JeongYeong;Jahng, Geon-Ho
通讯作者：
Jahng, Geon-Ho