EGFR and SYNE2 are associated with p21 expression and SYNE2 variants predict post-operative clinical outcomes in HBV-related hepatocellular carcinoma.
EGFR and SYNE2 are associated with p21 expression and SYNE2 variants predict post-operative clinical outcomes in HBV-related hepatocellular carcinoma.
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EGFR 和 SYNE2 与 p21 表达相关，SYNE2 变异可预测 HBV 相关肝细胞癌的术后临床结果
DOI：
10.1038/srep31237
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发表时间：
2016-08-09
影响因子：
4.6
通讯作者：
Peng T
中科院分区：
文献类型：
--
作者：
Han C;Liao X;Qin W;Yu L;Liu X;Chen G;Liu Z;Lu S;Chen Z;Su H;Zhu G;Lu Z;Liu Z;Qin X;Gui Y;Mo Z;Li L;Peng T
本研究旨在探讨广西乙型肝炎病毒（HBV）相关肝细胞癌（HCC）患者基因变异与p21表达之间的关联，并通过全基因组关联研究研究TP53独立的p21调控。 426 名 HBV 相关 HCC 患者入组。结果显示，经过质量控制，在 107 名 p21 阳性和 298 名 p21 阴性患者中总共鉴定出 21,643 个 SNP。表皮生长因子受体（EGFR；rs2227983 和 rs6950826）和含有血影蛋白重复序列的核膜 2（SYNE2；rs8010699、rs4027405 和 rs1890908）的变异与 p21 表达相关。此外，还鉴定了 EGFR 中的单倍型块（rs2227983 和 rs6950826，r2= 0.378）和 SYNE2 中的单倍型块（rs8010699 与 rs4027405 和 rs1890908 处于强 LD（r2= 0.91 和 0.70，分别）），并且单倍型EGFR的A-G和SYNE2的单倍型G-A-A与p21表达显着相关(P<0.01)。 rs4027405和rs1890908与总生存显着相关，SYNE2基因AG/GG基因型患者总生存较差(P= 0.001，P= 0.002)。我们的研究结果表明，EGFR 和 SYNE2 的变异在 p21 调节中发挥重要作用，并以独立于 TP53 的方式与 HBV 相关 HCC 的临床结果相关。
This study was to explore the association between gene variants and p21 expression and investigate the TP53-independent p21 regulation in hepatitis B virus (HBV) related hepatocellular carcinoma (HCC) patients from Guangxi by genome-wide association study. 426 HBV-related HCC patients were enrolled. Results showed that, after quality control, a total of 21,643 SNPs were identified in 107 p21 positive and 298 p21 negative patients. The variants of epidermal growth factor receptor (EGFR; rs2227983 and rs6950826) and spectrin repeat containing, nuclear envelope 2 (SYNE2; rs8010699, rs4027405 and rs1890908) were associated with p21 expression. Moreover the haplotype block (rs2227983 and rs6950826, r2= 0.378) in EGFR and the haplotype block in SYNE2 (rs8010699 was in strong LD with rs4027405 and rs1890908 (r2= 0.91 and 0.70, respectively)) were identified and the haplotype A-G of EGFR and haplotype G-A-A of SYNE2 were significantly associated with p21 expression (P< 0.01). rs4027405 and rs1890908 were significantly associated with overall survival and patients with AG/GG genotypes of SYNE2 gene had a worse overall survival (P= 0.001,P= 0.002). Our findings indicate that variants of EGFR and SYNE2 play an important role in p21 regulation and are associated with the clinical outcome of HBV-related HCC in a TP53-indenpdent manner.
P21WAF1/CIP1表达的丧失与胃癌中疾病进展相关。
影响因子：
8.8
作者：
Ogawa, M;Maeda, K;Onoda, N;Chung, Y S;Sowa, M
通讯作者：
Sowa, M