The type III secretion system of Pseudomonas aeruginosa: infection by injection.

The type III secretion system of Pseudomonas aeruginosa: infection by injection.
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DOI:
10.1038/nrmicro2199
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发表时间:
2009-09
期刊:
Nature reviews. Microbiology
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革兰氏阴性杆菌铜绿假单胞菌利用复杂的III型分泌装置将效应蛋白注入宿主细胞。这种分泌机制的结构,它注入的蛋白质的活动,以及这一过程对感染的后果现在正在被阐明。本文综述了我们目前对铜绿假单胞菌III型分泌物的认识,包括分泌和转位机制、该机制的调节以及相关的伴侣蛋白和效应器蛋白。这种有趣的分泌系统的特征对铜绿假单胞菌感染的发病机制和其他III型分泌系统具有重要的意义。
The Gram-negative bacterium Pseudomonas aeruginosa utilizes a complex type III secretion apparatus to inject effector proteins into host cells. The configuration of this secretion machinery, the activities of the proteins that are injected by it, and the consequences of this process to infection are now being elucidated. This Review summarizes our current knowledge of P. aeruginosa type III secretion, including the secretion and translocation machinery, the regulation of this machinery, and the associated chaperones and effector proteins. The features of this interesting secretion system have important implications to the pathogenesis of P. aeruginosa infections and to other type III secretion systems.
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