Animal models of cancer in the head and neck region.
Animal models of cancer in the head and neck region.
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DOI：
10.3342/ceo.2009.2.2.55
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发表时间：
2009-06
影响因子：
3
通讯作者：
Kim S
中科院分区：
文献类型：
--
作者：
Kim S
与头颈部癌症相似的动物模型对于研究这些疾病的癌变至关重要。虽然有几种方法可以模拟头颈部的癌症，但没有一种是完全令人满意的。裸鼠皮下肿瘤异种移植模型常用于临床前研究。然而，这些模型在几个方面存在问题，因为它们缺乏肿瘤细胞与其天然环境之间存在的特定相互作用。原位肿瘤的建立恢复了肿瘤与宿主器官之间相互作用的独特模式，而当肿瘤在异位部位建立时，这些模式就丢失或改变了。关于头颈部癌症的转基因模型，应该记住，用于驱动恶性转化的转基因可能并不代表在人类肿瘤中发现的致癌过程。肿瘤形成的低外显率也意味着使用转基因模型进行研究的高成本和时间投入。在这篇综述中，我们将讨论一些常用的模拟头颈部癌症的方法，包括头颈部鳞状细胞癌和甲状腺癌。
Animal models that resemble the cancers of the head and neck region are of paramount importance in studying the carcinogenesis of these diseases. Although several methods for modeling cancer in the head and neck are available, none are fully satisfactory. Subcutaneous xenograft models of cancer in nude mice are often used in preclinical studies. However, these models are problematic in several aspects as they lack the specific interactions that exist between the tumor cells and their native environment. Establishment of tumors at the orthotopic sites restore these distinct patterns of interactions between the tumor and the host organs that are lost or altered when the tumors are established in ectopic sites. With regard to the transgenic model of cancer in the head and neck region, it should be kept in mind that the transgene used to drive the malignant transformation may not be representative of the carcinogenic process found in human tumors. Low penetrance of tumor formation also translates into high cost and time commitment in performing studies with transgenic models. In this review, we will discuss some of the commonly used methods for modeling cancer in the head and neck region including squamous cell carcinoma of the head and neck as well as thyroid carcinoma.
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影响因子：
3.3
作者：
Lin, LM;Chen, YK;Huang, YL
通讯作者：
Huang, YL
影响因子：
7.6
作者：
Nishimura, A
通讯作者：
Nishimura, A
DOI：
10.1093/jnci/95.8.625
发表时间：
2003-04-16
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Cohen, J;Xing, MZ;Sidransky, D
通讯作者：
Sidransky, D
影响因子：
11.5
作者：
Kim, S;Park, YW;Myers, JN
通讯作者：
Myers, JN
影响因子：
11.2
作者：
Knauf, JA;Ma, XL;Fagin, JA
通讯作者：
Fagin, JA