Degenerative inter-vertebral disc disease osteochondrosis intervertebralis in Europe: prevalence, geographic variation and radiological correlates in men and women aged 50 and over.
Degenerative inter-vertebral disc disease osteochondrosis intervertebralis in Europe: prevalence, geographic variation and radiological correlates in men and women aged 50 and over.
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DOI：
10.1093/rheumatology/kex040
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发表时间：
2017-07-01
期刊：
影响因子：
--
通讯作者：
European Vertebral Osteoporosis Study and European Prospective Osteoporosis Study Groups
中科院分区：
文献类型：
--
作者：
Armbrecht G;Felsenberg D;Ganswindt M;Lunt M;Kaptoge SK;Abendroth K;Aroso Dias A;Bhalla AK;Cannata Andia J;Dequeker J;Eastell R;Hoszowski K;Lyritis G;Masaryk P;van Meurs J;Miazgowski T;Nuti R;Poór G;Redlund-Johnell I;Reid DM;Schatz H;Todd CJ;Woolf AD;Rivadeneira F;Javaid MK;Cooper C;Silman AJ;O'Neill TW;Reeve J;European Vertebral Osteoporosis Study and European Prospective Osteoporosis Study Groups
评估整个欧洲退行性椎间盘疾病 (DDD) 放射学指标的患病率；并量化它们与年龄、性别、体格测量、面积骨矿物质密度 (aBMD) 以及 aBMD 随时间变化的关系。在基于人口的欧洲前瞻性骨质疏松症研究中，来自欧洲大陆 50 岁以上男性和女性的 27 名年龄分层样本进行了腰椎和胸椎的标准化侧位 X 光检查，以使用 Kellgren-Lawrence (KL) 量表评估 DDD 的严重程度。对从 T4 到 L4 的所有评估椎骨的前部、中体和后部椎骨高度进行测量，用于生成终板曲率指数。来自 10,132 名参与者（56% 为女性，平均年龄 63.9 岁）的图像通过了质量检查。总体而言，47% 的男性和女性腰椎 DDD 为 3 级或以上，胸椎和腰椎均为 36%。根据年龄和人体测量决定因素调整后，3 级和 4 级 DDD 的风险比在各中心之间相差三倍，但男性和女性的患病率高度相关。 DDD 与扁平的、非卵形的椎间盘间隙有关。 KL 4 级和椎间盘间隙损失与较高的脊柱 aBMD 相关。 KL 3 级和 4 级在临床上经常用于对放射学 DDD 进行分类。随着人口老龄化，欧洲放射学定义的 DDD 3 级以上患病率差异很大，加上年龄的巨大影响，可能会对健康和经济产生日益增长的、地理上不平等的影响。这些数据鼓励进一步研究潜在的遗传和环境原因。
To assess the prevalence across Europe of radiological indices of degenerative inter-vertebral disc disease (DDD); and to quantify their associations with, age, sex, physical anthropometry, areal bone mineral density (aBMD) and change in aBMD with time. In the population-based European Prospective Osteoporosis Study 27 age-stratified samples of men and women from across the continent aged 50+ had standardized lateral radiographs of the lumbar and thoracic spine to evaluate the severity of DDD, using the Kellgren-Lawrence (KL) scale. Measurements of anterior, mid-body and posterior vertebral heights on all assessed vertebrae from T4 to L4 were used to generate indices of end-plate curvature. Images from 10,132 participants (56% female, mean age 63.9 years) passed quality checks. Overall, 47% of men and women had DDD grade 3 or more in the lumbar spine and 36% in both thoracic and lumbar spine. Risk ratios for DDD grades 3 and 4, adjusted for age and anthropometric determinants, varied across a three-fold range between centres, yet prevalences were highly correlated in men and women. DDD was associated with flattened, non-ovoid inter-vertebral disc spaces. KL grade 4 and loss of inter-vertebral disc space were associated with higher spine aBMD. KL Grades 3 and 4 are often used clinically to categorise radiological DDD. Highly variable European prevalences of radiologically-defined DDD Grades 3+ along with the large effects of age may have growing and geographically unequal health and economic impacts as the population ages. These data encourage further studies of potential genetic and environmental causes.
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影响因子：
2.8
作者：
Benneker, LM;Heini, PF;Ito, K
通讯作者：
Ito, K
影响因子：
27.4
作者：
KELLGREN, JH;LAWRENCE, JS
通讯作者：
LAWRENCE, JS
影响因子：
6.2
作者：
O'Neill, TW;Lunt, M;Reeve, J
通讯作者：
Reeve, J
影响因子：
4.7
作者：
Goode, Adam P.;Marshall, Stephen W.;Renner, Jordan B.;Carey, Timothy S.;Kraus, Virginia B.;Irwin, Debra E.;Stuermer, Til;Jordan, Joanne M.
通讯作者：
Jordan, Joanne M.
影响因子：
4
作者：
MCCLOSKEY, EV;SPECTOR, TD;KANIS, JA
通讯作者：
KANIS, JA