Pyridostigmine restores cardiac autonomic balance after small myocardial infarction in mice.
Pyridostigmine restores cardiac autonomic balance after small myocardial infarction in mice.
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DOI：
10.1371/journal.pone.0104476
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Salgado HC
中科院分区：
文献类型：
--
作者：
Durand MT;Becari C;de Oliveira M;do Carmo JM;Silva CA;Prado CM;Fazan R Jr;Salgado HC
吡斯的明 (PYR)（一种乙酰胆碱酯酶抑制剂）对血流动力学和心脏自主控制的影响从未在清醒的心肌梗塞小鼠中进行过研究。在异氟烷麻醉下将遥测发射器植入颈动脉。手术恢复后7至10天，记录基础动脉压和心率，同时通过甲基阿托品和普萘洛尔评估副交感神经和交感神经张力（ΔHR）。基础血流动力学记录后，对小鼠进行左冠状动脉结扎以产生心肌梗塞(MI)，或假手术，并植入充满PYR或盐水的微型泵。先前（4周）接受MI或假冠状动脉结扎的麻醉（异氟烷）小鼠的不同组进行心脏功能检查。小鼠的梗塞长度约为 12%，动脉压无变化，仅在 MI 后第一周心率增加。 MI后第1周迷走神经张力下降，而第1周和第4周交感神经张力增加。 PYR 可防止心率增加，但不会影响动脉压。此外，PYR 在 4 周内阻止了交感神经张力的增加。关于副交感神经张力，PYR不仅在第一周削弱其衰减，而且在第四周增强其衰减。 MI 降低射血分数并增加舒张压和收缩压。因此，通过 PYR 增加外周乙酰胆碱可用性的药理作用可以预防小鼠 MI 后的心动过速、副交感神经的增加和交感神经张力的降低。
The effect of pyridostigmine (PYR) - an acetylcholinesterase inhibitor - on hemodynamics and cardiac autonomic control, was never studied in conscious myocardial infarcted mice. Telemetry transmitters were implanted into the carotid artery under isoflurane anesthesia. Seven to ten days after recovery from the surgery, basal arterial pressure and heart rate were recorded, while parasympathetic and sympathetic tone (ΔHR) was evaluated by means of methyl atropine and propranolol. After the basal hemodynamic recording the mice were subjected to left coronary artery ligation for producing myocardial infarction (MI), or sham operation, and implantation of minipumps filled with PYR or saline. Separate groups of anesthetized (isoflurane) mice previously (4 weeks) subjected to MI, or sham coronary artery ligation, were submitted to cardiac function examination. The mice exhibited an infarct length of approximately 12%, no change in arterial pressure and increased heart rate only in the 1st week after MI. Vagal tone decreased in the 1st week, while the sympathetic tone was increased in the 1st and 4th week after MI. PYR prevented the increase in heart rate but did not affect the arterial pressure. Moreover, PYR prevented the increase in sympathetic tone throughout the 4 weeks. Concerning the parasympathetic tone, PYR not only impaired its attenuation in the 1st week, but enhanced it in the 4th week. MI decreased ejection fraction and increased diastolic and systolic volume. Therefore, the pharmacological increase of peripheral acetylcholine availability by means of PYR prevented tachycardia, increased parasympathetic and decreased sympathetic tone after MI in mice.
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DOI：
10.1152/ajpheart.01339.2006
发表时间：
2007-07-01
影响因子：
4.8
作者：
Dewland, Thomas A.;Androne, Ana Silvia;Katz, Stuart D.
通讯作者：
Katz, Stuart D.
影响因子：
5
作者：
Katare, Rajesh G.;Ando, Motonori;Sato, Takayuki
通讯作者：
Sato, Takayuki
影响因子：
5.7
作者：
Androne, AS;Hryniewicz, K;Katz, SD
通讯作者：
Katz, SD
影响因子：
5.9
作者：
Arenja, Nisha;Mueller, Christian;Zellweger, Michael J.
通讯作者：
Zellweger, Michael J.
影响因子：
4.8
作者：
Behling, A;Moraes, RS;Ribeiro, JP
通讯作者：
Ribeiro, JP