Protective Role of Melatonin and Its Metabolites in Skin Aging.
Protective Role of Melatonin and Its Metabolites in Skin Aging.
复制标题
DOI：
10.3390/ijms23031238
复制
发表时间：
2022-01-22
影响因子：
5.6
通讯作者：
Slominski AT
中科院分区：
文献类型：
--
作者：
Bocheva G;Slominski RM;Janjetovic Z;Kim TK;Böhm M;Steinbrink K;Reiter RJ;Kleszczyński K;Slominski AT
皮肤是人体最大的器官，暴露在环境中，既有内在的老化因素，也有外在的老化因素。皮肤老化过程的几个临床特征，如皱纹，失去弹性，和粗糙的纹理外观。这一复杂的过程伴随着皮肤和免疫细胞的表型和功能变化，以及细胞外基质成分(如胶原和弹性蛋白)的结构和功能障碍。因为皮肤健康被认为是代表人类整体“幸福”和“健康”认知的主要因素之一，所以最近已经开发了几种抗衰老策略。因此，虽然皮肤衰老的基本机制是已知的，但应考虑将新物质引入皮肤病治疗。在此，我们将褪黑素及其代谢物描述为潜在的“老化中和剂”。褪黑素是一种古老的5-羟色胺衍生物，具有激素特性，是松果体的主要神经内分泌产物。它调节昼夜节律，并发挥抗氧化、抗炎、免疫调节和抗肿瘤的能力。本文就皮肤衰老过程中的变化、导致这些变化的分子机制以及褪黑素及其代谢产物控制的褪黑素能抗氧化系统对皮肤衰老的影响等方面的研究进展进行综述。
The skin, being the largest organ in the human body, is exposed to the environment and suffers from both intrinsic and extrinsic aging factors. The skin aging process is characterized by several clinical features such as wrinkling, loss of elasticity, and rough-textured appearance. This complex process is accompanied with phenotypic and functional changes in cutaneous and immune cells, as well as structural and functional disturbances in extracellular matrix components such as collagens and elastin. Because skin health is considered one of the principal factors representing overall “well-being” and the perception of “health” in humans, several anti-aging strategies have recently been developed. Thus, while the fundamental mechanisms regarding skin aging are known, new substances should be considered for introduction into dermatological treatments. Herein, we describe melatonin and its metabolites as potential “aging neutralizers”. Melatonin, an evolutionarily ancient derivative of serotonin with hormonal properties, is the main neuroendocrine secretory product of the pineal gland. It regulates circadian rhythmicity and also exerts anti-oxidative, anti-inflammatory, immunomodulatory, and anti-tumor capacities. The intention of this review is to summarize changes within skin aging, research advances on the molecular mechanisms leading to these changes, and the impact of the melatoninergic anti-oxidative system controlled by melatonin and its metabolites, targeting the prevention or reversal of skin aging.
登录
查看更多内容
影响因子：
5.6
作者：
Alper, G;Girgin, FK;Ersöz, B
通讯作者：
Ersöz, B
影响因子：
56.9
作者：
AXELROD, J;WEISSBACH, H
通讯作者：
WEISSBACH, H
影响因子：
18.2
作者：
Campisi J
通讯作者：
Campisi J
影响因子：
--
作者：
Bi, Fangfang;Liu, Wenbo;Chang, Cuicui
通讯作者：
Chang, Cuicui
影响因子：
3.3
作者：
Brash DE
通讯作者：
Brash DE