Determining all parameters necessary to build Hill-type muscle models from experiments on single muscles.
Determining all parameters necessary to build Hill-type muscle models from experiments on single muscles.
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DOI：
10.1007/s00422-012-0531-5
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发表时间：
2012-11
影响因子：
1.9
通讯作者：
Bueschges, Ansgar
中科院分区：
文献类型：
--
作者：
Bluemel, Marcus;Hooper, Scott L.;Guschlbauer, Christoph;White, William E.;Bueschges, Ansgar
表征肌肉需要测量力-长度、力-激活和力-速度曲线等特性。这些表征需要大量的数据点，因为什么类型的函数（例如，线性的、指数的、双曲线的）最好地代表每种性质，并且需要确定相关方程中的参数值。因此，在任何一种肌肉的实验中，通常只测量几种特性，通过对大量肌肉的数据进行平均，可以获得完整的表征。这种平均方法可以很好地用于个体之间相似的肌肉。然而，相当多的证据表明，存在很大的个体间差异，至少对一些肌肉。这种变化给跨动物平均方法带来了困难。因此，在单个肌肉的实验中充分描述所有肌肉特性的方法将是有用的。之前对竹节虫伸肌的研究已经确定了描述这种肌肉特性的函数，并表明这些方程适用于所有动物。因此，在逐个个体的基础上表征这些肌肉只需要确定这些方程中的参数值，而不是方程形式。我们在这里提出的技术，允许确定所有这些参数值在实验中对单块肌肉。这种技术将使我们能够比较个体之间的参数变化，并单独建模肌肉。类似的实验也可以在其他系统的单个肌肉上进行。因此，这种方法可以提供一种广泛适用的方法，用于从单个实验中表征和建模肌肉。
Characterizing muscle requires measuring such properties as force–length, force–activation, and force–velocity curves. These characterizations require large numbers of data points because both what type of function (e.g., linear, exponential, hyperbolic) best represents each property, and the values of the parameters in the relevant equations, need to be determined. Only a few properties are therefore generally measured in experiments on any one muscle, and complete characterizations are obtained by averaging data across a large number of muscles. Such averaging approaches can work well for muscles that are similar across individuals. However, considerable evidence indicates that large inter-individual variation exists, at least for some muscles. This variation poses difficulties for across-animal averaging approaches. Methods to fully describe all muscle’s characteristics in experiments on individual muscles would therefore be useful. Prior work in stick insect extensor muscle has identified what functions describe each of this muscle’s properties and shown that these equations apply across animals. Characterizing these muscles on an individual-by-individual basis therefore requires determining only the values of the parameters in these equations, not equation form. We present here techniques that allow determining all these parameter values in experiments on single muscles. This technique will allow us to compare parameter variation across individuals and to model muscles individually. Similar experiments can likely be performed on single muscles in other systems. This approach may thus provide a widely applicable method for characterizing and modeling muscles from single experiments.
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影响因子：
1.9
作者：
Bluemel, Marcus;Guschlbauer, Christoph;Bueschges, Ansgar
通讯作者：
Bueschges, Ansgar
DOI：
10.1098/rspb.1938.0050
发表时间：
1938-10-01
期刊：
PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES
影响因子：
--
作者：
Hill, AV
通讯作者：
Hill, AV
影响因子：
2.5
作者：
Golowasch, J;Goldman, MS;Marder, E
通讯作者：
Marder, E
影响因子：
25
作者：
Schulz, DJ;Goaillard, JM;Marder, E
通讯作者：
Marder, E
影响因子：
8.2
作者：
LANGLOIS, JH;ROGGMAN, LA
通讯作者：
ROGGMAN, LA