DNA base-specific modulation of microampere transverse edge currents through a metallic graphene nanoribbon with a nanopore.
DNA base-specific modulation of microampere transverse edge currents through a metallic graphene nanoribbon with a nanopore.
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DOI：
10.1021/nl202870y
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发表时间：
2012-01-11
期刊：
影响因子：
10.8
通讯作者：
Nikolić BK
中科院分区：
文献类型：
--
作者：
Saha KK;Drndić M;Nikolić BK
我们研究了用于 DNA 测序的两端装置，该装置由具有锯齿形边缘的金属石墨烯纳米带 (ZGNR) 和其内部的纳米孔组成，DNA 分子通过该纳米孔进行易位。利用非平衡格林函数与密度泛函理论相结合，我们证明插入纳米孔的四个 DNA 核碱基中的每一个（其边缘碳原子被氢或氮钝化）都会导致器件电导发生独特的变化。与其他基于通过易位 DNA 的横向电子传输的最新生物传感器不同，这些生物传感器利用穿过纳米间隙或纳米孔的小（pA 量级）隧道电流，产生较差的信噪比，我们的设备概念依赖于这样一个事实：在 ZGNR 中，局部电流密度在边缘周围达到峰值，因此远离边缘钻纳米孔不会降低电导。在纳米孔中插入核碱基会影响周围区域的电荷密度，从而在偏置电压≃ 0.1 V下调制边缘传导电流，其幅度为μA量级。所提出的生物传感器不限于ZGNR，它们可以用支持横向边缘电流的其他纳米线来实现，例如手性GNR或由二维拓扑绝缘体制成的线。
We study two-terminal devices for DNA sequencing which consist of a metallic graphene nanoribbon with zigzag edges (ZGNR) and a nanopore in its interior through which the DNA molecule is translocated. Using the nonequilibrium Green functions combined with density functional theory, we demonstrate that each of the four DNA nucleobases inserted into the nanopore, whose edge carbon atoms are passivated by either hydrogen or nitrogen, will lead to a unique change in the device conductance. Unlike other recent biosensors based on transverse electronic transport through translocated DNA, which utilize small (of the order of pA) tunneling current across a nanogap or a nanopore yielding a poor signal-to-noise ratio, our device concept relies on the fact that in ZGNRs local current density is peaked around the edges so that drilling a nanopore away from the edges will not diminish the conductance. Inserting a nucleobase into the nanopore affects the charge density in the surrounding area, thereby modulating edge conduction currents whose magnitude is of the order of μA at bias voltage ≃ 0.1 V. The proposed biosensors are not limited to ZGNRs and they could be realized with other nanowires supporting transverse edge currents, such as chiral GNRs or wires made of two-dimensional topological insulators.
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