Estrogen regulation of duodenal bicarbonate secretion and sex-specific protection of human duodenum.
Estrogen regulation of duodenal bicarbonate secretion and sex-specific protection of human duodenum.
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DOI：
10.1053/j.gastro.2011.05.044
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发表时间：
2011-09
期刊：
影响因子：
29.4
通讯作者：
Dong H
中科院分区：
文献类型：
--
作者：
Tuo B;Wen G;Wei J;Liu X;Wang X;Zhang Y;Wu H;Dong X;Chow JY;Vallon V;Dong H
女性十二指肠溃疡患病率较低的原因尚不清楚。我们研究了雌激素是否调节人类十二指肠碳酸氢盐分泌（DBS），以及这一过程是否能解释十二指肠溃疡患病率的性别差异。
我们进行了一项流行病学研究，以将十二指肠溃疡患病率与性别和年龄相关联。对健康受试者测量了近端DBS。通过免疫印迹和免疫组化分析检测了人十二指肠黏膜中的雌激素受体表达。
在女性中，十二指肠溃疡的患病率明显低于男性。绝经前女性（20 - 49岁）患病率降低得最为显著，她们患十二指肠溃疡的可能性比年龄匹配的男性低3.91 - 5.09倍；在60岁及以上的受试者中，这种差异降至≤1.32倍。绝经前（20 - 29岁）女性，但绝经后（60 - 69岁）女性则不然，其基础和酸刺激的DBS明显高于年龄匹配的男性。绝经前女性（20 - 29岁）的基础和酸刺激的DBS明显高于绝经后女性（60 - 69岁），而20 - 29岁或60 - 69岁的男性之间在基础或酸刺激的DBS方面没有显著差异。绝经前女性在生理月经周期中，血清雌二醇水平与基础和酸刺激的DBS平行变化。17β - 雌二醇刺激的DBS与年龄或性别无关。在人十二指肠上皮细胞的质膜和胞质中检测到了雌激素受体α和β。
雌激素调节人类DBS，这可能降低女性患十二指肠溃疡的风险，并导致十二指肠溃疡患病率的性别差异。
The reason that women have a lower prevalence of duodenal ulcer is not clear. We investigated whether estrogen regulates human duodenal bicarbonate secretion (DBS) and whether this process accounts for sex differences in the prevalence of duodenal ulcer. We performed an epidemiological study to correlate duodenal ulcer prevalence with sex and age. Proximal DBS was measured from healthy subjects. Estrogen receptor expression was examined in human duodenal mucosa by immunoblot and immunohistochemical analyses. Among women, the prevalence of duodenal ulcer was significantly lower than among men. The reduced prevalence was greatest among premenopausal women (20–49 years), who were 3.91–5.09-fold less likely to develop duodenal ulcers than age-matched men; the difference was reduced to ≤1.32-fold among subjects 60 years or older. Premenopausal (20–29 years), but not post-menopausal (60–69 years) women, had significantly higher basal and acid-stimulated DBS than the age-matched men. Basal and acid-stimulated DBS in premenopausal women (20–29 years) were significantly higher than in post-menopausal women (60–69 years), whereas there were no significant differences in basal or acid-stimulated DBS between men that were 20–29 years old or 60–69 years old. Serum levels of estradiol changed in parallel with basal and acid-stimulated DBS during the physiological menstrual cycle in premenopausal women. 17β-estradiol-stimulated DBS was independent of age or sex. Estrogen receptors- and - were detected on plasma membrane and in cytosol of human duodenal epithelial cells. Estrogen regulates human DBS, which could reduce the risk for duodenal ulcer in women and contribute to sex differences in prevalence of duodenal ulcer.
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影响因子：
4.3
作者：
Dong, Wei-Guo;Cheng, Chun-Sheng;Yu, Jie-Ping
通讯作者：
Yu, Jie-Ping
影响因子：
7.3
作者：
Sato, Hiroyuki;Macchiarulo, Antonio;Auwerx, Johan
通讯作者：
Auwerx, Johan
影响因子：
2.3
作者：
Goodstadt, L.;Powell, T.;Figtree, G. A.
通讯作者：
Figtree, G. A.
影响因子：
12.7
作者：
KURATA, JH;HONDA, GD;FRANKL, H
通讯作者：
FRANKL, H
影响因子：
2.7
作者：
O'Mahony, Fiona;Harvey, Brian J.
通讯作者：
Harvey, Brian J.