Apoptotic Cell-Derived Extracellular Vesicles: More Than Just Debris.

Apoptotic Cell-Derived Extracellular Vesicles: More Than Just Debris.
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DOI:
10.3389/fimmu.2018.01486
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发表时间:
2018
影响因子:
7.3
通讯作者:
Poon IKH
Poon IKH
中科院分区:
医学2区
文献类型:
--
作者:
Caruso S;Poon IKH

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从健康细胞中释放的细胞外囊泡(EVs)如外泌体和微囊泡的许多功能已经被很好地表征,特别是与它们在免疫调节中的作用有关。凋亡小体是凋亡细胞分解过程中释放的一种主要的电动汽车,其他类型的电动汽车也从死亡细胞中释放出来,成为这一新兴领域的重要参与者。现在有越来越多的证据表明,细胞凋亡过程中产生的ev具有重要的免疫调节作用,这一概念与包括自身免疫、癌症和感染在内的不同疾病环境相关。因此,本文就细胞凋亡过程中EVs的形成可能是死亡细胞免疫调节的关键机制进行综述。
The many functions of extracellular vesicles (EVs) like exosomes and microvesicles released from healthy cells have been well characterized, particularly in relation to their roles in immune modulation. Apoptotic bodies, a major class of EV released as a product of apoptotic cell disassembly, and other types of EVs released from dying cells are also becoming recognized as key players in this emerging field. There is now increasing evidence to suggest that EVs produced during apoptosis have important immune regulatory roles, a concept relevant across different disease settings including autoimmunity, cancer, and infection. Therefore, this review focuses on how the formation of EVs during apoptosis could be a key mechanism of immune modulation by dying cells.
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