Reduced Cortico-Cortical Resting-State Connectivity in Sensory Systems Related to Bodily Pain in Juvenile Fibromyalgia.
Reduced Cortico-Cortical Resting-State Connectivity in Sensory Systems Related to Bodily Pain in Juvenile Fibromyalgia.
复制标题
与青少年纤维肌痛身体疼痛相关的感觉系统皮质-皮质静息态连接减少。
DOI：
10.1002/art.42691
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发表时间：
2024
期刊：
影响因子：
--
通讯作者：
López-Solà,Marina
中科院分区：
文献类型：
--
作者：
Suñol,Maria;Dudley,Jon;Payne,MichaelF;Tong,Han;Ting,TracyV;Kashikar-Zuck,Susmita;Coghill,RobertC;López-Solà,Marina
目的：青少年纤维肌痛（JFM）是一种典型的慢性疼痛疾病，其潜在的神经生物学基础尚不清楚。这项研究首次检测了37名患有JFM的女性青少年与43名健康女性青少年的数据驱动的静息状态功能连接（rsFC）改变，并确定了与身体疼痛的关联。方法采用内在连通性对比（每个体素的节点中心性度量）和基于种子的可解释性分析来评估全脑体素rsFC变化。我们研究了躯体感觉系统中rsFC的改变与身体疼痛的位置和延伸之间的关系。结果JFM青少年在中央旁小叶(PCL)/初级体感皮层（S1） （T = 4.89，家族误差校正p值(pFWE) < 0.001）和左中扣带皮层（T = 4.67, pFWE = 0.043）的体素方向rsFC降低。事后分析显示，跨越主要皮质感觉中枢的rsFC减少（T > 4.4, pFWE < 0.030）。JFM患者PCL/S1内皮质-皮质rsFC减少发生在疼痛最频繁的身体区域神经支配的位置（F = 3.15；阳性假发现率= 0.029），并预测了广泛的疼痛（T > 4.4, pFWE < 0.045）。相反，患有JFM的青少年PCL/ s1 -丘脑（T = 4.75, pFWE = 0.046）和PCL/ s1 -前岛rsFC （T = 5.13, pFWE = 0.039）增加。结论涉及PCL/S1并跨越感觉系统的皮质-皮质感觉统合减少可能是JFM青年患者关键疼痛感觉特征的基础。感觉整合的减少与感觉和情感/显著性处理区域之间的交叉对话的增强是平行的，这可能表明一种向更有情感色彩的感觉体验的转变，损害了特定的感觉歧视。
ObjectiveJuvenile‐onset fibromyalgia (JFM) is a paradigmatic chronic pain condition for which the underlying neurobiological substrates are poorly understood. This study examined, for the first time, data‐driven resting‐state functional connectivity (rsFC) alterations in 37 female adolescents with JFM compared with 43 healthy female adolescents and identified associations with bodily pain.MethodsWhole‐brain voxel‐wise rsFC alterations were assessed using the intrinsic connectivity contrast, a measure of node centrality at each voxel, and seed‐based analyses for interpretability. We studied the relationship between rsFC alterations in somatosensory systems and the location and extension of bodily pain.ResultsAdolescents with JFM had voxel‐wise rsFC reductions in the paracentral lobule (PCL)/primary somatosensory cortex (S1) (T = 4.89, family‐wise error corrected p‐value (pFWE) < 0.001) and left midcingulate cortex (T = 4.67, pFWE = 0.043). Post hoc analyses revealed reduced rsFC spanning major cortical sensory hubs (T > 4.4, pFWE < 0.030). Cortico‐cortical rsFC reductions within PCL/S1 in JFM occurred in locations innervated by bodily areas where the pain was most frequent (F = 3.15; positive false discovery rate = 0.029) and predicted widespread pain (T > 4.4, pFWE < 0.045). Conversely, adolescents with JFM had increases in PCL/S1–thalamus (T = 4.75, pFWE = 0.046) and PCL/S1–anterior insula rsFC (T = 5.13, pFWE = 0.039).ConclusionReduced cortico‐cortical sensory integration involving PCL/S1 and spanning the sensory systems may underly critical pain sensory features in youth with JFM. Reduced sensory integration is paralleled by augmented cross‐talk between sensory and affective/salience‐processing regions, potentially indicating a shift toward more affectively colored sensory experiences to the detriment of specific sensory discrimination.
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