Identification of Plant Soot as Novel Safe Feed Additive: Evaluation of 90-Day Oral Toxicity and Prenatal Developmental Toxicity in Rats.
Identification of Plant Soot as Novel Safe Feed Additive: Evaluation of 90-Day Oral Toxicity and Prenatal Developmental Toxicity in Rats.
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植物烟灰作为新型安全饲料添加剂的鉴定：大鼠 90 天口服毒性和产前发育毒性的评估。
DOI：
10.3389/fvets.2020.610627
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发表时间：
2020
影响因子：
3.2
通讯作者：
Tang S
中科院分区：
文献类型：
--
作者：
Pei X;Xiao X;Liao J;Ke L;Li D;Tang S
植物烟灰作为一种新型饲料添加剂，不仅能改善消化功能，而且能吸附霉菌毒素，抑制细菌感染。首次研究了植物煤烟的亚慢性毒性和产前发育效应。结果表明，饲料中添加2,000-50,000 mg/kg植物烟灰对孕鼠无亚慢性毒性，312.5、1,250和5,000 mg/kg植物烟灰对孕鼠生殖功能、胚胎发育和致畸性与对照组无显著差异。饲料中添加剂量的最大无明显作用水平（诺埃尔）可设定为50,000 mg/kg，胃内最大诺埃尔可设定为5,000 mg/kg，初步为植物烟灰的日添加量或临床方案提供了指导，也促进了这一无害抗生素替代品的开发和应用。
Plant soot, as a novel feed additive, could not only improve digestive function but also adsorb mycotoxins and inhibit bacterial infections. The subchronic toxicity and prenatal developmental effects of plant soot were studied for the first time. Our results indicated that there was no subchronic toxicity in the range of 2,000–50,000 mg/kg plant soot added in the feed, and there was no significant difference in reproductive function, embryo development, and teratogenicity between the pregnant rats exposed to 312.5, 1,250, and 5,000 mg/kg plant soot and the control group. The maximum no-observed effect level (NOEL) of supplemental dosage in feed could be set to 50,000 mg/kg, and the maximum intragastric NOEL could be set to 5,000 mg/kg, which preliminarily provided guidance on daily additive amount or clinical protocols for plant soot, as well as promoting the development and application of this harmless antibiotic substitutes.
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