B cell abnormalities in systemic lupus erythematosus.
B cell abnormalities in systemic lupus erythematosus.
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DOI：
10.1186/ar1009
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发表时间：
2003
影响因子：
4.9
通讯作者：
Lipsky PE
中科院分区：
文献类型：
--
作者：
Grammer AC;Lipsky PE
系统性红斑狼疮（SLE）是一种慢性、多系统的自身免疫性疾病，其特征在于分泌致病性自身抗体的短寿命和长寿命免疫球蛋白分泌浆细胞的分化。在狼疮性肾炎肾脏中观察到异位生发中心和分泌自身抗体的浆细胞。SLE的候选遗传易感性基因座包括影响浆细胞的分化和存活的基因，例如影响参与生发中心产生的体液免疫的T和B细胞的活化、增殖、细胞因子和趋化因子分泌/反应性以及凋亡的基因，以及参与通过抗原呈递细胞和其它吞噬细胞呈递和清除凋亡物质和自身抗原的基因。新出现的数据表明，B淋巴细胞是体液免疫应答的积极参与者，通过同型CD 154-CD 40相互作用以及通过B细胞成熟抗原、B细胞活化因子受体和跨膜活化剂由B细胞活化因子的持续刺激，导致分泌免疫球蛋白的浆细胞的T依赖性和T非依赖性分化。
Systemic lupus erythematosus (SLE) is a chronic, multisystem autoimmune disease characterized by the differentiation of short- and long-lived immunoglobulin secreting plasma cells that secrete pathogenic autoantibodies. Ectopic germinal centers and plasma cells secreting autoantibodies have been observed in lupus nephritis kidneys. Candidate genetic susceptibility loci for SLE include genes that affect differentiation and survival of plasma cells, such as those that influence activation, proliferation, cytokine and chemokine secretion/responsiveness, and apoptosis of the T and B cells that are involved in humoral immunity generated in germinal centers, as well as genes that are involved in presentation and clearance of apoptotic material and autoantigens by antigen presenting cells and other phagocytes. Emerging data have demonstrated that B lymphocytes are active participants in humoral immune responses that lead to T-dependent and T-independent differentiation of immunoglobulin-secreting plasma cells by homotypic CD154–CD40 interactions as well as continued stimulation by B cell activating factor through B cell maturation antigen, B cell activating factor receptor and transmembrane activater.
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DOI：
10.1084/jem.179.2.425
发表时间：
1994-02-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Cooke MP;Heath AW;Shokat KM;Zeng Y;Finkelman FD;Linsley PS;Howard M;Goodnow CC
通讯作者：
Goodnow CC
影响因子：
15.9
作者：
Grammer, AC;Slota, R;Lipsky, PE
通讯作者：
Lipsky, PE
影响因子：
4.4
作者：
Higuchi, T;Aiba, Y;Tsubata, T
通讯作者：
Tsubata, T
DOI：
10.1073/pnas.221456898
发表时间：
2001-10-23
影响因子：
11.1
作者：
Ferrari, S;Giliani, S;Plebani, A
通讯作者：
Plebani, A
DOI：
10.1073/pnas.050580697
发表时间：
2000-03-28
影响因子：
11.1
作者：
Khare, SD;Sarosi, I;Hsu, HL
通讯作者：
Hsu, HL