Sustained Effectiveness of the Maternal Pertussis Immunization Program in England 3 Years Following Introduction.
Sustained Effectiveness of the Maternal Pertussis Immunization Program in England 3 Years Following Introduction.
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DOI：
10.1093/cid/ciw559
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发表时间：
2016-12-01
期刊：
影响因子：
--
通讯作者：
Andrews N
中科院分区：
文献类型：
--
作者：
Amirthalingam G;Campbell H;Ribeiro S;Fry NK;Ramsay M;Miller E;Andrews N
在2012年推出使用白喉-破伤风-5组分无细胞百日咳灭活脊髓灰质炎疫苗(dT5aP-IPV)的计划一年后，英国首次展示了母亲免疫在预防婴儿百日咳方面的有效性。尽管更换了另一种具有不同抗原成分的无细胞疫苗，但疫苗对实验室确认的百日咳疫苗的效力在引入后的3年内一直保持在90%。与此一致的是，尽管1岁及以上婴儿的高活动率持续存在，但3个月大婴儿的发病率仍然很低。疫苗对婴儿死亡的有效性估计为95%(95%可信区间，79%-100%)。在接受初级系列疫苗第一剂的婴儿中，保留了对产妇免疫的额外保护。不再有证据表明，在第三次婴儿接种后，孕妇接种疫苗会有额外的保护作用。虽然人数很少，而且需要进行持续评估，但没有证据表明母亲接种母体疫苗的婴儿在初级免疫后患病风险增加。
The effectiveness of maternal immunization in preventing infant pertussis was first demonstrated in England, 1 year after the program using diphtheria–tetanus–5-component acellular pertussis–inactivated polio vaccine (dT5aP-IPV) was introduced in 2012. Vaccine effectiveness against laboratory-confirmed pertussis has been sustained >90% in the 3 years following its introduction, despite changing to another acellular vaccine with different antigen composition. Consistent with this, disease incidence in infants <3 months of age has remained low despite high activity persisting in those aged 1 year and older. Vaccine effectiveness against infant deaths was estimated at 95% (95% confidence interval, 79%–100%). Additional protection from maternal immunization is retained in infants who received their first dose of the primary series. There is no longer evidence of additional protection from maternal vaccination after the third infant dose. Although numbers are small and ongoing assessment is required, there is no evidence of increased risk of disease after primary immunization in infants whose mothers received maternal vaccination.
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影响因子：
168.9
作者：
Amirthalingam, Gayatri;Andrews, Nick;Ramsay, Mary
通讯作者：
Ramsay, Mary
影响因子：
11.8
作者：
Dabrera, Gavin;Amirthalingam, Gayatri;Ramsay, Mary
通讯作者：
Ramsay, Mary
DOI：
10.1136/bmj.g4219
发表时间：
2014-07-11
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Donegan K;King B;Bryan P
通讯作者：
Bryan P
影响因子：
7.7
作者：
FARRINGTON, CP
通讯作者：
FARRINGTON, CP
影响因子：
3
作者：
Fry, Norman K.;Litt, David J.;Harrison, Timothy G.
通讯作者：
Harrison, Timothy G.