Angiopoietin-like 3 Is a Potential Biomarker for Retinopathy in Type 2 Diabetic Patients.
Angiopoietin-like 3 Is a Potential Biomarker for Retinopathy in Type 2 Diabetic Patients.
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血管生成素样 3 是 2 型糖尿病患者视网膜病变的潜在生物标志物。
DOI：
10.1016/j.ajo.2018.03.040
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发表时间：
2018-07
期刊：
影响因子：
--
通讯作者：
Feng Ying-Mei
中科院分区：
文献类型：
--
作者：
Yu;Cai-Guo;Yuan;Sha-Sha;Yang;Long-Yan;Ke;Jing;Zhang;Li-Jie;Yu Cai-Guo;Yuan Sha-Sha;Yang Long-Yan;Ke Jing;Zhang Li-Jie;Lang Jia-Nan;Zhang Da-Wei;Zhao Shao-Zhen;Zhao Dong;Feng Ying-Mei
目的探讨血管生成素样蛋白3（ANGPTL 3）和血管生成素样蛋白4（ANGPTL 4）是否与2型糖尿病（T2 DM）患者视网膜病变的严重程度有差异。设计横断面研究。方法血清ANGPTL 3、ANGPTL 4、高敏C反应蛋白（CRP）、血管黏附分子-1（VCAM-1）、细胞内黏附分子-1（ICAM-1）、和血管内皮生长因子（VEGF）通过ELISA定量。记录视网膜图像以评估糖尿病视网膜病变（DR）的分级。进行多变量调整的logistic分析，以估计每个生物标志物和DR stage.ResultsAmong 1192 T2 DM患者，426（35.7%）有非增殖性糖尿病视网膜病变（NPDR）和56（4.5%）有增殖性糖尿病视网膜病变（PDR）的关联。在调整协变量后，表达DR与无DR风险的比值比（n = 710 vs 482）为1.23（95%置信区间[CI]，1.08- 1.40，P = .002）; ANGPTL 4为0.90（95% CI，0.79-1.02;P= .095）; VEGF为1.14（95% CI，1.00-1.29;P= .044）。无DR vs NPDR（n = 710 vs 426）的风险为ANGPTL 3 1.16（95% CI，1.01-1.32;P= .036）; ANGPTL 4 0.90（95% CI，0.79-1.04;P= .15）; VEGF 1.14（95% CI，1.00-1.31;P= .045）。NPDR与PDR的比值比（n = 426 vs 56）为1.47（95% CI，1.03-2.10;P= .035）血清ANGPTL 3; 0.96 VEGF为1.05（95%CI，0.77-1.45; P= .74）。结论ANGPTL 3与DR各期进展独立且强相关。阻断视网膜ANGPTL 3信号可能延缓糖尿病视网膜病变的发生和发展。
PurposeTo investigate whether angiopoietin-like 3 (ANGPTL3) and angiopoietin-like 4 (ANGPTL4) are differentially associated with the severity of retinopathy in patients with type 2 diabetes mellitus (T2DM).DesignCross-sectional study.MethodsSerum levels of ANGPTL3, ANGPTL4, high-sensitivity C-reactive protein (CRP), vascular adhesion molecule–1 (VCAM-1), intracellular adhesion molecule–1 (ICAM-1), and vascular endothelial growth factor (VEGF) were quantified by ELISA. Retinal images were recorded to assess the grade of diabetic retinopathy (DR). Multivariable-adjusted logistic analysis was performed to estimate the association of each biomarker and DR stage.ResultsAmong 1192 T2DM patients, 426 (35.7%) had nonproliferative diabetic retinopathy (NPDR) and 56 (4.5%) had proliferative diabetic retinopathy (PDR). After adjusting for covariables, the odds ratios expressing the risk of having DR vs no DR (n = 710 vs 482) were 1.23 (95% confidence interval [CI], 1.08-1.40,P= .002) for ANGPTL3; 0.90 (95% CI, 0.79-1.02;P= .095) for ANGPTL4; and 1.14 (95% CI, 1.00-1.29;P= .044) for VEGF. The risk of having no DR vs NPDR (n = 710 vs 426) was 1.16 (95% CI, 1.01-1.32;P= .036) for ANGPTL3; 0.90 (95% CI, 0.79-1.04;P= .15) for ANGPTL4; and 1.14 (95% CI, 1.00-1.31;P= .045) for VEGF. The odds ratios of having NPDR vs PDR (n = 426 vs 56) was 1.47 (95% CI, 1.03-2.10;P= .035) for serum ANGPTL3; 0.96 (95% CI, 0.69-1.35;P= .83) for ANGPTL4; and 1.05 (95% CI, 0.77-1.45;P= .74) for VEGF.ConclusionsANGPTL3 is independently and strongly associated with DR progression in all stages. Blockade of ANGPTL3 signal in retina might postpone the onset and development of DR in T2DM patients.
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DOI：
10.1161/atvbaha.113.302802
发表时间：
2014-05
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Mehta N;Qamar A;Qu L;Qasim AN;Mehta NN;Reilly MP;Rader DJ
通讯作者：
Rader DJ
影响因子：
3.8
作者：
Abu El-Asrar, Ahmed M.;Mohammad, Ghulam;Opdenakker, Ghislain
通讯作者：
Opdenakker, Ghislain
ANGPTL3-4-8 模型，甘油三酯运输的分子机制。
影响因子：
5.8
作者：
Zhang R
通讯作者：
Zhang R
影响因子：
13.7
作者：
Kuo JZ;Guo X;Klein R;Klein BE;Cui J;Rotter JI;Ipp E;Chen YD
通讯作者：
Chen YD
影响因子：
2.9
作者：
Wei Li;Wei Sun;Chuanhua Yang;Hong-zhen Hu;Yuehua Jiang
通讯作者：
Wei Li;Wei Sun;Chuanhua Yang;Hong-zhen Hu;Yuehua Jiang