Systemic soluble tumor necrosis factor receptors 1 and 2 are associated with severity of diabetic retinopathy in Hispanics.
Systemic soluble tumor necrosis factor receptors 1 and 2 are associated with severity of diabetic retinopathy in Hispanics.
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DOI：
10.1016/j.ophtha.2011.10.040
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发表时间：
2012-05
期刊：
影响因子：
13.7
通讯作者：
Chen YD
中科院分区：
文献类型：
--
作者：
Kuo JZ;Guo X;Klein R;Klein BE;Cui J;Rotter JI;Ipp E;Chen YD
目的探讨拉美裔人群血清淀粉样蛋白A(SAA)和可溶性肿瘤坏死因子受体1、2(sTNF-R1、sTNF-R2)与糖尿病视网膜病变(DR)的关系。前瞻性、非随机、横断面、以家庭为基础的观察性队列研究。采用双抗体夹心酶联免疫吸附试验(EL ISA)检测473例西班牙裔2型糖尿病家系受试者的血清sSAA、sTFR1、sTFR2水平。用眼底照相对DR进行评估，并用改良的Airlie House分类法对DR进行分级。有无协变量时SAA、sTNF-R1和sTNF-R2水平与DR严重程度的关系。在无糖尿病视网膜病变、轻度非增殖性糖尿病视网膜病变、中度非增殖性糖尿病视网膜病变、重度糖尿病视网膜病变和增殖性糖尿病视网膜病变中，sTNF-R2的表达水平分别为0.0001、6.04±0.20、6.25±0.52、7.96±0.70、8.14±1.13、14.83±1.68 ng/ml，与糖尿病视网膜病变呈正相关。在调整了年龄、性别、体重指数、血红蛋白A1c、糖尿病病程、收缩压和血肌酐后，这些相关性仍然显著(p<；sTNF-R1为0.0001，sTNF-R2为p=0.0004)。当我们调整尿白蛋白与肌酐的比率而不是血肌酐时，也观察到了类似的模式(sTNF-R1的p=0.005，sTNF-R2的p=0.02)。STNF-R1和sTNF-R2水平与DR的严重程度高度相关，提示炎症和胰岛素抵抗可能在DR的发生发展中起关键作用，这些可能是DR的有用生物标志物，有助于病因学研究，并可能在识别高危患者进行积极干预方面提供帮助。
To investigate the associations of serum amyloid A protein (SAA) and soluble tumor necrosis factor receptors 1 and 2 (sTNF-R1 and sTNF-R2) with diabetic retinopathy (DR) in Hispanics. Prospective, nonrandomized, cross-sectional, family-based observational cohort study. Four hundred seventy-three Hispanics type II diabetic subjects, in families ascertained via proband with DR. Levels of SAA, sTNF-R1, and sTNF-R2 were measured with enzyme-linked immunosorbent assay (ELISA). DR was assessed by fundus photography and graded using modified Airlie House classification. Levels of SAA, sTNF-R1, and sTNF-R2 to severity of DR with and without covariates. A direct association of sTNF-R1 (2.37±0.13, 2.15±0.09, 3.09±0.24, 3.25±0.46, 5.02±0.61 ng/ml; p<0.0001) and sTNF-R2 (6.04±0.20, 6.25±0.52, 7.96±0.70, 8.14±1.13, 14.83±1.68 ng/ml; p<0.0001) was found for no DR, mild non-proliferative DR (NPDR), moderate NPDR, severe NPDR, and proliferative DR (PDR), respectively. These associations remained significant after adjusting for age, gender, body mass index, hemoglobin A1c, diabetes duration, systolic blood pressure, and serum creatinine (p<0.0001 for sTNF-R1 and p=0.0004 for sTNF-R2). A similar pattern was observed when we adjusted for urinary albumin-to-creatinine ratio in place of serum creatinine (p=0.005 for sTNF-R1 and p=0.02 for sTNF-R2). Levels of sTNF-R1 and sTNF-R2 are highly correlated with severity of DR, suggesting that inflammation and insulin resistance may play a critical role in the development of DR. These may be useful biomarkers for DR, aiding in etiologic studies, and possibly in identifying at-risk patients for active intervention.
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DOI：
10.1073/pnas.041359198
发表时间：
2001-02-27
影响因子：
11.1
作者：
Fukumura, D;Gohongi, T;Jain, RK
通讯作者：
Jain, RK
影响因子：
4.2
作者：
Varma, Rohit;Choudhury, Farzana;Klein, Ronald;Chung, Jessica;Torres, Mina;Azen, Stanley P.
通讯作者：
Azen, Stanley P.
肿瘤坏死因子-α的脂肪表达--在与肥胖相关的胰岛素抵抗中的直接作用
影响因子：
56.9
作者：
HOTAMISLIGIL, GS;SHARGILL, NS;SPIEGELMAN, BM
通讯作者：
SPIEGELMAN, BM
影响因子：
16.2
作者：
Harris, MI;Klein, R;Byrd-Holt, DD
通讯作者：
Byrd-Holt, DD
影响因子：
16.2
作者：
West, SK;Klein, R;Snyder, R
通讯作者：
Snyder, R