How robust is a neural circuit?

How robust is a neural circuit?
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神经回路的鲁棒性如何?

DOI:
10.1017/s0952523807070526
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发表时间:
2007
影响因子:
1.9
通讯作者:
Freed,Michael
Freed,Michael
中科院分区:
医学4区
文献类型:
--
作者:
Sterling,Peter;Freed,Michael

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工程设计始于鲁棒性问题--固有容量应超出正常需求多少倍?在这里,我们认为鲁棒性的神经回路,从视锥细胞到神经节细胞的视网膜。电路的任务是在许多连续的阶段代表视觉场景,每一次都是通过调制一系列随机事件:光异构化,然后是发射量子,然后是尖峰。在早期阶段,事件速率很高,以达到一定的临界信噪比和时间带宽,这两者共同决定了信息速率。然后神经电路集中信息并重新包装,以便通过调制低得多的事件率来表示几乎相同的总信息。这对于加标很重要,因为它的代谢成本很高。考虑到在外层和内层视网膜的各种测量,我们得出结论,“安全系数”约为2-10,与其他组织相似。
Design in engineering begins with the problem of robustness—by what factor should intrinsic capacity exceed normal demand? Here we consider robustness for a neural circuit that crosses the retina from cones to ganglion cells. The circuit's task is to represent the visual scene at many successive stages, each time by modulating a stream of stochastic events: photoisomerizations, then transmitter quanta, then spikes. At early stages, the event rates are high to achieve some critical signal-to-noise ratio and temporal bandwidth, which together set the information rate. Then neural circuits concentrate the information and repackage it, so that nearly the same total information can be represented by modulating far lower event rates. This is important for spiking because of its high metabolic cost. Considering various measurements at the outer and inner retina, we conclude that the “safety factors” are about 2–10, similar to other tissues.
外视网膜的光适应和对比度。
DOI: --
发表时间: 2001
影响因子: --
作者:
D. A. Burkhardt
通讯作者: D. A. Burkhardt
DOI: 10.1016/s0896-6273(01)00243-4
发表时间: 2001-03-01
期刊: NEURON
影响因子: 16.2
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发表时间: 2006-11
影响因子: 2.5
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Zhen-Yu Zhou;Qunfang Wan;P. Thakur;R. Heidelberger
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DOI: 10.1098/rstb.1990.0201
发表时间: 1990-12-29
影响因子: 6.3
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通讯作者: STERLING, P
DOI: 10.1016/s0896-6273(00)00011-8
发表时间: 2000-07-01
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通讯作者: Wässle, H