Mitocans Revisited: Mitochondrial Targeting as Efficient Anti-Cancer Therapy.
Mitocans Revisited: Mitochondrial Targeting as Efficient Anti-Cancer Therapy.
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DOI：
10.3390/ijms21217941
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发表时间：
2020-10-26
影响因子：
5.6
通讯作者：
Neuzil J
中科院分区：
文献类型：
--
作者：
Dong L;Gopalan V;Holland O;Neuzil J
线粒体是重要的细胞器，控制着细胞存活和细胞死亡的多个关键信号通路。越来越多的证据表明，线粒体代谢和功能在肿瘤发生和癌症进展中是不可或缺的，使得线粒体和线粒体功能成为抗癌治疗的合理靶点。本文综述了选择性靶向线粒体的主要策略及其在抗癌中的作用，包括靶向线粒体代谢、电子传递链和三羧酸循环、线粒体氧化还原信号通路和ROS稳态。我们强调，将抗癌药物递送到线粒体中对于未来的癌症治疗策略具有巨大的潜力，具有潜在克服耐药性的巨大优势。Mitocans，例如以维生素E琥珀酸酯和他莫昔芬（MitoTam）为例，选择性地靶向癌细胞线粒体，并通过破坏线粒体功能有效地杀死多种类型的癌细胞，MitoTam目前正在进行临床试验。
Mitochondria are essential cellular organelles, controlling multiple signalling pathways critical for cell survival and cell death. Increasing evidence suggests that mitochondrial metabolism and functions are indispensable in tumorigenesis and cancer progression, rendering mitochondria and mitochondrial functions as plausible targets for anti-cancer therapeutics. In this review, we summarised the major strategies of selective targeting of mitochondria and their functions to combat cancer, including targeting mitochondrial metabolism, the electron transport chain and tricarboxylic acid cycle, mitochondrial redox signalling pathways, and ROS homeostasis. We highlight that delivering anti-cancer drugs into mitochondria exhibits enormous potential for future cancer therapeutic strategies, with a great advantage of potentially overcoming drug resistance. Mitocans, exemplified by mitochondrially targeted vitamin E succinate and tamoxifen (MitoTam), selectively target cancer cell mitochondria and efficiently kill multiple types of cancer cells by disrupting mitochondrial function, with MitoTam currently undergoing a clinical trial.
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影响因子：
50.3
作者：
Chae YC;Caino MC;Lisanti S;Ghosh JC;Dohi T;Danial NN;Villanueva J;Ferrero S;Vaira V;Santambrogio L;Bosari S;Languino LR;Herlyn M;Altieri DC
通讯作者：
Altieri DC
影响因子：
7.4
作者：
Dong, Lan-Feng;Jameson, Victoria J. A.;Neuzil, Jiri
通讯作者：
Neuzil, Jiri
影响因子：
7.7
作者：
Dong, Lan-Feng;Kovarova, Jaromira;Neuzil, Jiri
通讯作者：
Neuzil, Jiri
DOI：
10.1016/j.bbagrm.2012.06.002
发表时间：
2012-09
影响因子：
4.7
作者：
Cline, Susan D.
通讯作者：
Cline, Susan D.
影响因子：
5.7
作者：
Boukalova, Stepana;Stursa, Jan;Neuzil, Jiri
通讯作者：
Neuzil, Jiri