Expression of CD147, PCNA, VEGF, MMPs and their clinical significance in the giant cell tumor of bones.
Expression of CD147, PCNA, VEGF, MMPs and their clinical significance in the giant cell tumor of bones.
复制标题
CD147、PCNA、VEGF、MMPs在骨巨细胞瘤中的表达及其临床意义
DOI：
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发表时间：
2015-07
期刊：
影响因子：
--
通讯作者：
Luo Zhuo-Jing
中科院分区：
文献类型：
--
作者：
Han Yue-Hu;Gao Bo;Huang Jing-Hui;Wang Zhen;Guo Zheng;Jie Qiang;Yang Liu;Luo Zhuo-Jing
背景
BACKGROUND
Giant cell tumor of bone (GCT) is a potentially malignant tumor. CD147 is a multifunctional protein, which expresses itself in many tumors. In this study, we have investigated the correlation between CD147 and PCNA, VEGF, MMPs expression in giant cell tumor of bones. We have also explored the relationship between its clinical pathology and prognosis.
RESULTS
A significant difference of the expression level of CD147, MMPs was found in cases of GCT with Jaffe grading and prognosis (P<0.05). But, it was not in accordance with the patient's age and sex. An expression of CD147 was positively correlated with MMP-9, VEGF, MVD, PCNA (r=0.271, P=0.025; r=0.411, P=0.000; r=0.872, P=0.000; r=0.394, P=0.001).
CONCLUSION
The expression level of CD147 in giant cell tumors of bones is correlated with the development of cancers and relapse. There was a positive correlation between expressions of CD147 and MMP-9, VEGF, MVD, PCNA, and CD147. This is an important indicator in evaluating the malignant degree and prognosis of giant cell tumors of bone. It may be the new target for ensuring chemopreventive strategies.
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影响因子：
4.3
作者：
Kataoka, Hiroaki;Tanaka, Hiroyuki;Itoh, Hiroshi
通讯作者：
Itoh, Hiroshi
影响因子：
7.3
作者：
Nabeshima, K;Suzumiya, J;Kikuchi, M
通讯作者：
Kikuchi, M
影响因子：
5.2
作者：
Tang, Yi;Nakada, Marian T.;Yan, Li
通讯作者：
Yan, Li
影响因子：
4.7
作者：
A. Westerlund;E. Hujanen;U. Puistola;T. Turpeenniemi‐Hujanen
通讯作者：
A. Westerlund;E. Hujanen;U. Puistola;T. Turpeenniemi‐Hujanen
影响因子：
2.8
作者：
忠彦 猪鹿倉
通讯作者：
忠彦 猪鹿倉