Anti-citrullinated peptide antibody assays and their role in the diagnosis of rheumatoid arthritis.
Anti-citrullinated peptide antibody assays and their role in the diagnosis of rheumatoid arthritis.
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DOI：
10.1002/art.24827
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发表时间：
2009-11-15
影响因子：
--
通讯作者：
Costenbader, Karen H.
中科院分区：
文献类型：
--
作者：
Aggarwal, Rohit;Liao, Katherine;Nair, Raj;Ringold, Sarah;Costenbader, Karen H.
越来越多的抗瓜氨酸肽抗体（ACPA）检测方法用于RA诊断。本文综述了ACPA检测的生物学基础和发展，现有的ACPA检测方法及其性能特点，ACPA单独和类风湿因子（RF）在早期RA中的诊断特性。我们还审查了相关性，精密度，成本和成本效益，可用性，稳定性和重现性的可用检测。结果表明，ACPA对早期RA的诊断特异性高于RF，预测效度好，敏感性高，成本效益明显，稳定性和重复性好。鉴于其上级性能特征和日益增加的可用性，ACPA正在成为诊断RA的最有用的单一检测方法。
Increasingly, assays for the detection of anti-citrullinated peptide antibodies (ACPA) are used in RA diagnosis. This review summarizes the biologic basis and development of ACPA assays, available ACPA assays and their performance characteristics, and diagnostic properties of ACPA alone and compared to rheumatoid factor (RF) in early RA. We also review correlations, precision, costs and cost-effectiveness, availability, stability and reproducibility of the available assays. Taken together, data indicate that ACPA has a higher specificity than RF for early RA, good predictive validity, high sensitivity, apparent cost-effectiveness and good stability and reproducibility. Given its superior performance characteristics and increasing availability, ACPA is emerging as the most useful single assay for the diagnosis of RA.
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影响因子：
--
作者：
Bang, Holger;Egerer, Karl;Burmester, Gerd-R.
通讯作者：
Burmester, Gerd-R.
影响因子：
27.4
作者：
Berglin, E;Johansson, T;Rantapää-Dahlqvist, S
通讯作者：
Rantapää-Dahlqvist, S
影响因子：
3.4
作者：
Candia, Liliana;Marquez, Javier;Espinoza, Luis R.
通讯作者：
Espinoza, Luis R.
影响因子：
--
作者：
Bukhari, MAS;Wiles, NJ;Silman, AJ
通讯作者：
Silman, AJ
影响因子：
3.4
作者：
Ates, Askin;Karaaslan, Yasar;Aksaray, Sebahat
通讯作者：
Aksaray, Sebahat