Engineering and physical sciences in oncology: challenges and opportunities.
Engineering and physical sciences in oncology: challenges and opportunities.
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DOI：
10.1038/nrc.2017.83
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发表时间：
2017-11
期刊：
影响因子：
--
通讯作者：
Langer R
中科院分区：
文献类型：
--
作者：
Mitchell MJ;Jain RK;Langer R
工程学和物理学的原理应用于肿瘤学已有近50年的历史。工程师和物理科学家为癌症生物学的各个方面做出了贡献，从肿瘤生长和进展的定量理解到改进癌症的检测和治疗。许多早期的努力集中在药物分布，细胞周期动力学和肿瘤生长动力学的实验和计算建模。在过去的十年中，我们目睹了工程学，物理学和肿瘤学界面的指数增长，这些增长受到材料科学，微制造，纳米医学，微流体学，成像等领域的进步的推动，并受到美国国立卫生研究院（NIH）新计划的催化，包括国家生物医学成像和生物工程研究所（NIBIB），肿瘤学物理科学，和国家癌症研究所（NCI）纳米技术联盟。在这里，我们回顾了在工程和物理科学和肿瘤学的接口在四个重要领域取得的进展：肿瘤的物理微环境和药物输送的技术进步;细胞和分子成像;和微流体和微加工。我们讨论了将工程和物理科学与肿瘤学相结合以开发研究，检测和治疗癌症的新方法的研究进展，机遇和挑战，我们还描述了这些新兴领域的未来前景。
The principles of engineering and physics have been applied to oncology for nearly 50 years. Engineers and physical scientists have made contributions to all aspects of cancer biology, from quantitative understanding of tumour growth and progression to improved detection and treatment of cancer. Many early efforts focused on experimental and computational modelling of drug distribution, cell cycle kinetics and tumour growth dynamics. In the past decade, we have witnessed exponential growth at the interface of engineering, physics and oncology that has been fuelled by advances in fields including materials science, microfabrication, nanomedicine, microfluidics, imaging, and catalysed by new programmes at the National Institutes of Health (NIH), including the National Institute of Biomedical Imaging and Bioengineering (NIBIB), Physical Sciences in Oncology, and the National Cancer Institute (NCI) Alliance for Nanotechnology. Here, we review the advances made at the interface of engineering and physical sciences and oncology in four important areas: the physical microenvironment of the tumour and technological advances in drug delivery; cellular and molecular imaging; and microfluidics and microfabrication. We discussthe research advances, opportunities and challenges for integrating engineering and physical sciences with oncology to develop new methods to study, detect and treat cancer, and we also describe the future outlook for these emerging areas.
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影响因子：
3.7
作者：
Cheng G;Tse J;Jain RK;Munn LL
通讯作者：
Munn LL
DOI：
10.1126/science.1198704
发表时间：
2011-05-06
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Bendall SC;Simonds EF;Qiu P;Amir el-AD;Krutzik PO;Finck R;Bruggner RV;Melamed R;Trejo A;Ornatsky OI;Balderas RS;Plevritis SK;Sachs K;Pe'er D;Tanner SD;Nolan GP
通讯作者：
Nolan GP
影响因子：
5.5
作者：
Carey, Shawn P.;Rahman, Aniqua;Reinhart-King, Cynthia A.
通讯作者：
Reinhart-King, Cynthia A.
影响因子：
6
作者：
Conklin, Matthew W.;Eickhoff, Jens C.;Keely, Patricia J.
通讯作者：
Keely, Patricia J.
影响因子：
28.1
作者：
Bruns, Oliver T.;Bischof, Thomas S.;Bawendi, Moungi G.
通讯作者：
Bawendi, Moungi G.