Angiogenesis in spontaneous tumors and implications for comparative tumor biology.
Angiogenesis in spontaneous tumors and implications for comparative tumor biology.
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DOI：
10.1155/2014/919570
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发表时间：
2014
影响因子：
--
通讯作者：
Gärtner F
中科院分区：
文献类型：
--
作者：
Benazzi C;Al-Dissi A;Chau CH;Figg WD;Sarli G;de Oliveira JT;Gärtner F
血液供应对于肿瘤的发展和生长是必不可少的，而血管生成是从先前存在的血管形成新血管的基本过程。血管生成是多种肿瘤的预后指标，并且与肿瘤细胞脱落进入循环和转移的增加相一致。几种分子如细胞表面受体、生长因子和酶参与这一过程。虽然20多年前就提出了癌症的抗血管生成疗法，但近年来在科学界引起了很大争议。血管生成信号级联和抗血管生成物质之间的复杂关系表明血管生成途径是抗癌药物开发的有效靶点，VEGF已成为主要的抗血管生成药物靶点。这篇综述讨论了血管生成的基础和临床前景，强调了比较生物学在理解肿瘤血管生成和整合这些模型系统用于未来药物开发中的重要性。
Blood supply is essential for development and growth of tumors and angiogenesis is the fundamental process of new blood vessel formation from preexisting ones. Angiogenesis is a prognostic indicator for a variety of tumors, and it coincides with increased shedding of neoplastic cells into the circulation and metastasis. Several molecules such as cell surface receptors, growth factors, and enzymes are involved in this process. While antiangiogenic therapy for cancer has been proposed over 20 years ago, it has garnered much controversy in recent years within the scientific community. The complex relationships between the angiogenic signaling cascade and antiangiogenic substances have indicated the angiogenic pathway as a valid target for anticancer drug development and VEGF has become the primary antiangiogenic drug target. This review discusses the basic and clinical perspectives of angiogenesis highlighting the importance of comparative biology in understanding tumor angiogenesis and the integration of these model systems for future drug development.
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影响因子：
1.7
作者：
Bowden, J;Brennan, PA;Cronin, A
通讯作者：
Cronin, A
DOI：
10.1038/nrc2442
发表时间：
2008-08
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
通讯作者：
--
影响因子：
3.1
作者：
AUSPRUNK, DH;FOLKMAN, J
通讯作者：
FOLKMAN, J
影响因子：
--
作者：
CADUFF, JH;FISCHER, LC;BURRI, PH
通讯作者：
BURRI, PH
影响因子：
56.9
作者：
Bergers, G;Javaherian, K;Hanahan, D
通讯作者：
Hanahan, D