4D registration and 4D verification of lung tumor position for stereotactic volumetric modulated arc therapy using respiratory-correlated cone-beam CT.
4D registration and 4D verification of lung tumor position for stereotactic volumetric modulated arc therapy using respiratory-correlated cone-beam CT.
复制标题
DOI：
10.1093/jrr/rrs058
复制
发表时间：
2013-01
影响因子：
2
通讯作者：
Yoda K
中科院分区：
文献类型：
--
作者：
Nakagawa K;Haga A;Kida S;Masutani Y;Yamashita H;Takahashi W;Sakumi A;Saotome N;Shiraki T;Ohtomo K;Iwai Y;Yoda K
我们提出了一种利用4D计划CT和4D锥束CT(CBCT)从计划到肿瘤位置验证的立体定向体积调制弧形治疗(VMAT)的临床流程。应用4DCT扫描仪、Anzai腰带和BodyFix获得一例肺患者在呼吸受限条件下的10期呼吸相关CT数据。通过向从10个临床目标体积创建的内部目标体积添加5 mm边距来定义计划目标体积(PTV)，每个临床目标体积在10个阶段的计划CT数据中的每一个上描绘。在最大呼气期CT图像上建立单弧形VMAT计划，D95处方剂量为50Gy四次扫描。将PTV轮廓输出到配备有直线加速器(直线加速器)的千伏CBCT X射线体积成像(XVI)。在治疗前，10期4D CBCT图像被重建，从而产生了肺肿瘤的动画成像。在帧平均的4D计划CT和帧平均的4D CBCT数据集之间执行初始骨匹配。随后，在XVI监视器上同时显示导入的PTV轮廓和动画移动的肿瘤，并在监视器上交互执行手动4D配准，直到移动的肿瘤对称地定位在PTV内。将VMAT射束传送给患者，并在传送过程中进一步采集4D CBCT投影数据以验证肿瘤位置。对每个片段重复整个过程。证实在VMAT交付过程中，移动的肿瘤位于PTV内部。
We propose a clinical workflow of stereotactic volumetric modulated arc therapy (VMAT) for a lung tumor from planning to tumor position verification using 4D planning computed tomography (CT) and 4D cone-beam CT (CBCT). A 4D CT scanner, an Anzai belt and a BodyFix were employed to obtain 10-phase respiratory-correlated CT data for a lung patient under constrained breathing conditions. A planning target volume (PTV) was defined by adding a 5-mm margin to an internal target volume created from 10 clinical target volumes, each of which was delineated on each of the 10-phase planning CT data. A single-arc VMAT plan was created with a D95 prescription dose of 50 Gy in four fractions on the maximum exhalation phase CT images. The PTV contours were exported to a kilovoltage CBCT X-ray Volume Imaging (XVI) equipped with a linear accelerator (linac). Immediately before treatment, 10-phase 4D CBCT images were reconstructed leading to animated lung tumor imaging. Initial bone matching was performed between frame-averaged 4D planning CT and frame-averaged 4D CBCT datasets. Subsequently, the imported PTV contours and the animated moving tumor were simultaneously displayed on the XVI monitor, and a manual 4D registration was interactively performed on the monitor until the moving tumor was symmetrically positioned inside the PTV. A VMAT beam was delivered to the patient and during the delivery further 4D CBCT projection data were acquired to verify the tumor position. The entire process was repeated for each fraction. It was confirmed that the moving tumor was positioned inside the PTV during the VMAT delivery.
登录
查看更多内容
影响因子：
168.9
作者：
Shirato, H;Shimizu, S;Miyasaka, K
通讯作者：
Miyasaka, K
影响因子：
5.7
作者：
Korreman, Stine S.;Juhler-Nottrup, Trine;Boyer, Arthur L.
通讯作者：
Boyer, Arthur L.
DOI：
10.1186/1748-717x-6-4
发表时间：
2011-01-12
期刊：
Radiation oncology (London, England)
影响因子：
--
作者：
Wang X;Xiong XP;Lu J;Zhu GP;He SQ;Hu CS;Ying HM
通讯作者：
Ying HM
DOI：
10.1016/s0360-3016(99)00056-5
发表时间：
1999-07-01
影响因子：
7
作者：
Wong, JW;Sharpe, MB;Martinez, AA
通讯作者：
Martinez, AA
影响因子：
3.8
作者：
Sonke, JJ;Zijp, L;van Herk, M
通讯作者：
van Herk, M