The Schizosaccharomyces pombe map1 gene encodes an SRF / MCM1-related protein required for P-cell specific gene expression
The Schizosaccharomyces pombe map1 gene encodes an SRF / MCM1-related protein required for P-cell specific gene expression
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粟酒裂殖酵母map1基因编码P细胞特异性基因表达所需的SRF/MCM1相关蛋白
DOI：
10.1007/pl00008604
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
S. Kjærulff
中科院分区：
文献类型：
--
作者：
Olaf Nielsen;T. Friis;S. Kjærulff
摘要裂殖酵母 细胞在缺乏氮源的情况下进行交配和减数分裂。在这个过程中，P细胞和M细胞首先交配产生二倍体受精卵，然后进入减数分裂并形成孢子。P交配型由交配型基因座的mat1-Pc基因和一种称为map1的基因共同控制。我们证明了这两个功能是P-特异性基因map3表达所必需的。我们已经克隆了MAP1基因，并证明它编码一个可能的MADS-box，其中包含与哺乳动物血清反应因子(SRF)和酿酒酵母MCM1相关的转录因子。Mat1-Pc蛋白含有与MADS-box因子相互作用的蛋白质的基序特征，提示Mat-Pc和Map1可能形成一个异源二聚体，激活P-特异性Map3基因。
Abstract Cells of Schizosaccharomyces pombe undergo mating and meiosis when starved for a nitrogen source. In this process a P and an M cell first mate to generate a diploid zygote, which subsequently enters meiosis and sporulates. The P mating type is controlled by the mat1-Pc gene at the mating type locus, together with a gene called map1. We show that these two functions are required for expression of the P-specific gene map3. We have cloned the map1 gene and show that it encodes a putative MADS-box containing transcription factor related to mammalian Serum Response Factor (SRF) and Saccharomyces cerevisiae MCM1. The Mat1-Pc protein contains a motif characteristic for proteins that interact with MADS-box factors, suggesting that Mat-Pc and Map1 may form a heterodimer that activates the P-specific map3 gene.
酵母中细胞身份与信号响应的耦合：α1 和 STE12 蛋白之间的相互作用。
影响因子：
10.5
作者：
Yuan,YO;Stroke,IL;Fields,S
通讯作者：
Fields,S
影响因子：
3.5
作者：
HENIKOFF, S
通讯作者：
HENIKOFF, S