Role of the axonal initial segment in psychiatric disorders: function, dysfunction, and intervention.
Role of the axonal initial segment in psychiatric disorders: function, dysfunction, and intervention.
复制标题
DOI：
10.3389/fpsyt.2014.00109
复制
发表时间：
2014
影响因子：
4.7
通讯作者：
Laezza F
中科院分区：
文献类型：
--
作者：
Hsu WC;Nilsson CL;Laezza F
由于缺乏对潜在的细胞和功能机制的理解，开发有效的精神疾病干预措施的进展受到限制。最近的研究结果集中在探索精神疾病的新原因，强调了轴突初始段（AIS）的重要性，这是一个高度专业化的神经元结构，对动作电位的尖峰起始至关重要。特别是，电压门控钠通道的作用，以及它们与其他蛋白质伙伴在严格调节的大分子复合物中的相互作用，被强调为神经元兴奋性调节的关键组成部分。兴奋性的缺陷和过度与脑部疾病的发病机制有关。确定AIS正常功能或其中断所涉及的因素和调控途径，可以导致针对这些机制相互作用的新型干预措施的发展，提高治疗效果，同时减少对精神疾病的有害脱靶效应。
The progress of developing effective interventions against psychiatric disorders has been limited due to a lack of understanding of the underlying cellular and functional mechanisms. Recent research findings focused on exploring novel causes of psychiatric disorders have highlighted the importance of the axonal initial segment (AIS), a highly specialized neuronal structure critical for spike initiation of the action potential. In particular, the role of voltage-gated sodium channels, and their interactions with other protein partners in a tightly regulated macromolecular complex has been emphasized as a key component in the regulation of neuronal excitability. Deficits and excesses of excitability have been linked to the pathogenesis of brain disorders. Identification of the factors and regulatory pathways involved in proper AIS function, or its disruption, can lead to the development of novel interventions that target these mechanistic interactions, increasing treatment efficacy while reducing deleterious off-target effects for psychiatric disorders.
登录
查看更多内容
DOI：
10.1083/jcb.200805169
发表时间：
2008-12-15
期刊：
The Journal of cell biology
影响因子：
--
作者：
Bréchet A;Fache MP;Brachet A;Ferracci G;Baude A;Irondelle M;Pereira S;Leterrier C;Dargent B
通讯作者：
Dargent B
影响因子：
3.5
作者：
Cho, Ellen;Fogel, Brent L.
通讯作者：
Fogel, Brent L.
影响因子：
4
作者：
Drumheller, T;McGillivray, BC;Smith, DI
通讯作者：
Smith, DI
影响因子：
4.1
作者：
Budni, Josiane;Lobato, Kelly R.;Rodrigues, Ana Lucia S.
通讯作者：
Rodrigues, Ana Lucia S.
影响因子：
4.7
作者：
Cimarosti, Helena;Kantamneni, Sriharsha;Henley, Jeremy M.
通讯作者：
Henley, Jeremy M.