Enhanced SOX2 expression in retinoblastoma tissues and peripheral blood is associated with the clinicopathological characteristics of the disease.
Enhanced SOX2 expression in retinoblastoma tissues and peripheral blood is associated with the clinicopathological characteristics of the disease.
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视网膜母细胞瘤组织和外周血中SOX2表达增强与该疾病的临床病理特征相关
DOI：
10.3892/ol.2015.2857
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发表时间：
2015-03
期刊：
影响因子：
2.9
通讯作者：
Xiong W
中科院分区：
文献类型：
--
作者：
Tong B;Zeng J;Wu Y;Xiong W
本研究旨在探讨视网膜母细胞瘤（Rb）组织和外周血中性别决定区Y box 2 （SOX2）的表达与Rb临床病理特征的关系。免疫组化染色和western blot检测SOX2在Rb组织中的表达。采用实时定量聚合酶链反应检测Rb患儿外周血中SOX2的表达。采用χ2检验分析SOX2表达与Rb临床病理特征的相关性。SOX2在Rb组织中的阳性率为82.2%，而在对照组组织中SOX2的表达为阴性。Western blot检测到SOX2在Rb组织中的表达高于对照组组织。低分化Rb组织中SOX2的表达水平明显高于高分化Rb组织。Rb患儿外周血SOX2表达高于对照组。低分化组外周血SOX2表达水平高于高分化组。SOX2在Rb组织和外周血中的表达增强与Rb的临床病理特征密切相关。因此，SOX2可能成为Rb临床诊断和治疗的新靶点生物标志物。
The present study aimed to investigate the association between the expression of sex-determining region Y box 2 (SOX2) in retinoblastoma (Rb) tissues and peripheral blood, and the clinicopathological characteristics of Rb. The expression of SOX2 in Rb tissues was detected by immunohistochemical staining and western blot analysis. SOX2 expression in the peripheral blood of children with Rb was determined using quantitative real-time polymerase chain reaction. The correlation between SOX2 expression and the clinicopathological characteristics of Rb was analyzed using χ2 tests. The positive rate of SOX2 in Rb tissues was 82.2%, while the expression of SOX2 in the control group tissues was negative. Western blot analysis detected a higher expression of SOX2 in the Rb tissues than in the control group tissues. Poorly differentiated Rb tissues exhibited significantly higher levels of SOX2 expression compared with the well-differentiated Rb tissues. SOX2 expression was higher in the peripheral blood of children with Rb than in individuals from the control group. The level of SOX2 expression in the peripheral blood of the poorly differentiated group was higher than that of the well-differentiated group. Enhanced SOX2 expression in Rb tissues and peripheral blood was closely associated with the clinicopathological characteristics of Rb. Therefore, SOX2 may be a novel target biomarker for the clinical diagnosis and treatment of Rb.
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影响因子：
64.8
作者：
Zhang, Jinghui;Benavente, Claudia A.;McEvoy, Justina;Flores-Otero, Jacqueline;Ding, Li;Chen, Xiang;Ulyanov, Anatoly;Wu, Gang;Wilson, Matthew;Wang, Jianmin;Brennan, Rachel;Rusch, Michael;Manning, Amity L.;Ma, Jing;Easton, John;Shurtleff, Sheila;Mullighan, Charles;Pounds, Stanley;Mukatira, Suraj;Gupta, Pankaj;Neale, Geoff;Zhao, David;Lu, Charles;Fulton, Robert S.;Fulton, Lucinda L.;Hong, Xin;Dooling, David J.;Ochoa, Kerri;Naeve, Clayton;Dyson, Nicholas J.;Mardis, Elaine R.;Bahrami, Armita;Ellison, David;Wilson, Richard K.;Downing, James R.;Dyer, Michael A.
通讯作者：
Dyer, Michael A.
DOI：
10.1111/j.1749-6632.2012.06772.x
发表时间：
2012-01-01
期刊：
MYASTHENIA GRAVIS AND RELATED DISORDERS II
影响因子：
--
作者：
Lipka, Alexander F.;Verschuuren, Jan J. G. M.;Titulaer, Maarten J.
通讯作者：
Titulaer, Maarten J.
影响因子：
23.9
作者：
Sarkar, Abby;Hochedlinger, Konrad
通讯作者：
Hochedlinger, Konrad
影响因子：
4.8
作者：
Chou, Ming-Yung;Hu, Fang-Wei;Yu, Cheng-Chia
通讯作者：
Yu, Cheng-Chia
影响因子：
1.2
作者：
Jehanne, Mathilde;Brisse, Herve;Aerts, Isabelle
通讯作者：
Aerts, Isabelle