Racial Health Disparity and COVID-19.
Racial Health Disparity and COVID-19.
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DOI：
10.1007/s11481-021-10014-7
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发表时间：
2021-12
期刊：
影响因子：
--
通讯作者：
Bissler J
中科院分区：
文献类型：
--
作者：
Kumar S;Kumar P;Kodidela S;Duhart B;Cernasev A;Nookala A;Kumar A;Singh UP;Bissler J
严重急性呼吸道综合征冠状病毒2型（SARS-CoV-2）和由此产生的冠状病毒疾病19（COVID-19）的感染对少数民族，特别是非洲裔美国人（AA）的影响与白人人口相比。AA人群受到COVID-19的严重影响，部分原因是他们的肥胖、糖尿病和高血压等基础疾病患病率很高，已知这些疾病不仅会加重肾脏疾病，还会加重COVID-19。此外，吸烟者对COVID-19指南的依从性降低可能导致感染、炎症增加、免疫反应降低和肺损伤，从而导致更严重的COVID-19。由于AA人群中导致肾脏疾病的基础疾病的高患病率加上吸烟使AA人群容易受到严重形式的COVID-19和肾脏疾病的影响。在这篇综述中，我们描述了吸烟如何与SARS-CoV-2相互作用，并加剧SARS-CoV-2诱导的肾脏疾病，包括肾衰竭，特别是在AA人群中。我们还探索了细胞外囊泡（EV）在吸烟的COVID-19患者中的作用。EV在烟草介导的感染性疾病发病机制中发挥重要作用，也已显示在COVID-19发病机制和包括肾脏在内的器官损伤中发挥重要作用。此外，我们探索了电动汽车在生物标志物发现和治疗中的潜在作用，这可能有助于开发COVID-19患者烟草诱导的肾损伤的早期诊断和治疗。
The infection by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and resultant coronavirus diseases-19 (COVID-19) disproportionally affects minorities, especially African Americans (AA) compared to the Caucasian population. The AA population is disproportionally affected by COVID-19, in part, because they have high prevalence of underlying conditions such as obesity, diabetes, and hypertension, which are known to exacerbate not only kidney diseases, but also COVID-19. Further, a decreased adherence to COVID-19 guidelines among tobacco smokers could result in increased infection, inflammation, reduced immune response, and lungs damage, leading to more severe form of COVID-19. As a result of high prevalence of underlying conditions that cause kidney diseases in the AA population coupled with tobacco smoking make the AA population vulnerable to severe form of both COVID-19 and kidney diseases. In this review, we describe how tobacco smoking interact with SARS-CoV-2 and exacerbates SARS-CoV-2-induced kidney diseases including renal failure, especially in the AA population. We also explore the role of extracellular vesicles (EVs) in COVID-19 patients who smoke tobacco. EVs, which play important role in tobacco-mediated pathogenesis in infectious diseases, have also shown to be important in COVID-19 pathogenesis and organ injuries including kidney. Further, we explore the potential role of EVs in biomarker discovery and therapeutics, which may help to develop early diagnosis and treatment of tobacco-induced renal injury in COVID-19 patients, respectively.
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影响因子：
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作者：
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影响因子：
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作者：
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DOI：
10.2215/cjn.12191018
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