Changes in airway bacterial communities occur soon after initiation of antibiotic treatment of pulmonary exacerbations in cystic fibrosis.
Changes in airway bacterial communities occur soon after initiation of antibiotic treatment of pulmonary exacerbations in cystic fibrosis.
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DOI：
10.1016/j.jcf.2022.05.011
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发表时间：
2022-09
影响因子：
5.2
通讯作者：
LiPuma, John J.
中科院分区：
文献类型：
--
作者：
Carmody, Lisa A.;Kalikin, Linda M.;VanDevanter, Donald R.;Li, Gen;Opron, Kristopher;Simon, Richard H.;Caverly, Lindsay J.;LiPuma, John J.
慢性多微生物气道感染是囊性纤维化（CF）肺病的标志。抗生素治疗是CF肺加重（PEX）的主要治疗方法;然而，间歇性抗生素治疗对气道细菌群落的影响尚未得到很好的描述。我们分析了在PEx抗生素治疗之前和期间立即获得的CF成人痰液样本。细菌16 S核糖体RNA基因的V4区的测序用于评估抗生素治疗期间细菌群落结构的变化。抗生素治疗的峰值影响在治疗的第四天或第五天观察到。这些发现促进了我们对抗生素治疗期间细菌群落动态的理解，并补充了最近和正在进行的评价抗生素治疗最佳持续时间的研究。
Chronic polymicrobial airway infections are a hallmark of cystic fibrosis (CF) lung disease. Antibiotic therapy is a primary treatment of CF pulmonary exacerbations (PEx); however, the impact of episodic antibiotic treatment on airway bacterial communities has not been well described. We analyzed sputum samples from adults with CF obtained immediately before and during antibiotic treatment of PEx. Sequencing of the V4 region of the bacterial 16S ribosomal RNA gene was used to assess changes in bacterial community structure during antibiotic treatment. The peak impact of antibiotic treatment was observed by day four or five of treatment. These findings advance our understanding of bacterial community dynamics during antibiotic treatment of PEx and complement recent and ongoing studies evaluating the optimal duration of antibiotic therapy for PEx.
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影响因子：
48
作者：
Callahan BJ;McMurdie PJ;Rosen MJ;Han AW;Johnson AJ;Holmes SP
通讯作者：
Holmes SP
影响因子：
8.3
作者：
Caverly, Lindsay J.;Lu, Junnan;LiPuma, John J.
通讯作者：
LiPuma, John J.
影响因子：
6.1
作者：
BRAY, J. ROGER;CURTIS, J. T.
通讯作者：
CURTIS, J. T.
影响因子：
4.4
作者：
Lozupone, Catherine A.;Hamady, Micah;Knight, Rob
通讯作者：
Knight, Rob
DOI：
10.1164/rccm.202102-0461oc
发表时间：
2021-12-01
影响因子：
24.7
作者：
Goss, Christopher H.;Heltshe, Sonya L.;Flume, Patrick A.
通讯作者：
Flume, Patrick A.