Chitosan and chitosan coating nanoparticles for the treatment of brain disease
Chitosan and chitosan coating nanoparticles for the treatment of brain disease
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DOI：
10.1016/j.ijpharm.2019.02.012
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发表时间：
2019-04
影响因子：
5.8
通讯作者：
Hu Kaili
中科院分区：
文献类型：
--
作者：
Yu Shuangwen;Xu Xiaolu;Feng Jianfang;Liu Mei;Hu Kaili
自1993年Gallo将壳聚糖磁性阳离子微球应用于脑给药以来，壳聚糖在脑给药方面的研究得到了广泛的关注。壳聚糖作为唯一一种具有良好生物相容性和生物降解性的天然碱性多糖，以壳聚糖为载体材料制备的纳米粒包裹药物，具有抗酶降解、控制释放、提高生物利用度等优点。此外，壳聚糖可通过影响紧密连接增强药物透过血脑屏障的能力。壳聚糖纳米粒表面带正电荷，可吸附在带负电荷的细胞膜上，从而增加其在鼻粘膜上的停留时间，有利于药物从鼻腔向脑的传递。所有这些特性使得壳聚糖纳米颗粒特别适合于脑递送。更重要的是，壳聚糖纳米颗粒表面的游离氨基允许特定的化学修饰，形成广泛的壳聚糖衍生物。用肿瘤靶向肽如氯毒素和转铁蛋白对纳米粒进行表面修饰，可进一步提高其对脑肿瘤的靶向性。本文就壳聚糖纳米粒的优点及其在脑疾病治疗中的研究进展作一综述。
Since the application of chitosan magnetic cationic microspheres in brain drug delivery by Gallo in 1993, chitosan has been extensively studied in brain drug delivery. As the only natural alkaline polysaccharide with good biocompatibility and biodegradability, chitosan prepared nanoparticles which use chitosan as carrier material to encapsulate drug have been proved with advantages of protecting from enzyme degradation, control release and improved bioavailability. Besides, chitosan can enhance drug permeability across the blood-brain barrier by affecting the tight junction. And with positive charge on the surface, chitosan nanoparticles can absorb on the negatively charged cell membrane, thus increase its residence time on the nasal mucosa and benefit of the delivery of drugs from the nasal cavity to the brain. All these properties made chitosan nanoparticles especially suitable for brain delivery. What’s more, the free amino groups on the surface of chitosan nanoparticles allow specific chemical modification to form a wide range of chitosan derivatives. Surface modification of the nanoparticles with tumor targeting peptides like chlorotoxin and transferrin, can further improve the targeting property to brain tumor. This article gives a comprehensive review on the advantages and recent progresses in the treatment of brain disease by chitosan nanoparticles.
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DOI：
10.1016/j.jconrel.2016.02.032
发表时间：
2015-11
期刊：
Journal of controlled release : official journal of the Controlled Release Society
影响因子：
--
作者：
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发表时间：
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影响因子：
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影响因子：
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作者：
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