Endothelins in inflammatory neurological diseases.
Endothelins in inflammatory neurological diseases.
复制标题
DOI：
10.1016/j.pharmthera.2018.10.001
复制
发表时间：
2019-03
影响因子：
13.5
通讯作者：
Desruisseaux MS
中科院分区：
文献类型：
--
作者：
D'Orléans-Juste P;Akide Ndunge OB;Desbiens L;Tanowitz HB;Desruisseaux MS
内皮素是三十多年前发现的一种有效的血管活性化合物。然而，除了它们已被证实的血管调节特性外，内皮素途径在几个神经炎症过程中的作用已经被证明，并且这些肽被报道为神经退行性疾病的临床相关生物标记物。一些已发表的研究表明，内皮素-1极大地促进了神经炎性过程的进展，特别是在中枢神经系统(CNS)感染期间，并与血脑屏障水平的内皮完整性丧失有关。由于内皮素-1拮抗剂在几种感染性和非感染性神经炎症性疾病中的临床试验很少，所以21个氨基酸的多肽是否是神经退行性变的介质而不是生物标记物仍然是一个悬而未决的问题。本文综述了内皮素在神经炎症过程中的潜在作用，包括病毒、细菌或寄生虫性疾病，在这些疾病中，内皮素的合成或药理已从细胞到床边进行了研究，以及非传染性炎症过程，如阿尔茨海默病或中枢神经系统血管炎等神经退行性疾病。
Endothelins were discovered more than thirty years ago as potent vasoactive compounds. Beyond their well-documented vasomodulatory properties, however, the contributions of the endothelin pathway have been demonstrated in several neuroinflammatory processes and the peptides have been reported as a clinically relevant biomarkers in neurodegenerative diseases. Several published works suggest that endothelin-1 greatly contributes to the progression of neuroinflammatory processes, particularly during infections in the central nervous system (CNS), and is associated with a loss of endothelial integrity at the blood brain barrier level. Because of the paucity of clinical trials with endothelin-1 antagonists in several infectious and non-infectious neuroinflammatory diseases, it remains an open question whether the 21 amino acid peptide is a mediator rather than a biomarker of the progression of neurodegeneration. The present review focuses on the potential roles of endothelins in the pathology of neuroinflammatory processes, including infectious diseases of viral, bacterial or parasitic origin in which the synthesis of endothelins or its pharmacology have been investigated from the cell to the bedside in several cases, and non-infectious inflammatory processes such as neurodegenerative disorders like Alzheimers Disease or central nervous system vasculitis.
登录
查看更多内容
影响因子：
2.1
作者：
Basu, Atanu;Yadav, Pragya;Mourya, Devendra T.
通讯作者：
Mourya, Devendra T.
影响因子：
6.4
作者：
Avalos CR;Abreu CM;Queen SE;Li M;Price S;Shirk EN;Engle EL;Forsyth E;Bullock BT;Mac Gabhann F;Wietgrefe SW;Haase AT;Zink MC;Mankowski JL;Clements JE;Gama L
通讯作者：
Gama L
DOI：
10.1093/brain/awu040
发表时间：
2014-05
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Barker R;Ashby EL;Wellington D;Barrow VM;Palmer JC;Kehoe PG;Esiri MM;Love S
通讯作者：
Love S
影响因子：
82.9
作者：
Bateman, Randall J.;Munsell, Ling Y.;Holtzman, David M.
通讯作者：
Holtzman, David M.
影响因子：
4.4
作者：
ADAMS, CWM;POSTON, RN;VIPOND, H
通讯作者：
VIPOND, H