Independent representations of self-motion and object location in barrel cortex output.
Independent representations of self-motion and object location in barrel cortex output.
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DOI：
10.1371/journal.pbio.3000882
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发表时间：
2020-11
期刊：
影响因子：
9.8
通讯作者：
Hires SA
中科院分区：
文献类型：
--
作者：
Cheung JA;Maire P;Kim J;Lee K;Flynn G;Hires SA
在主动触觉探索过程中，触觉的动态模式被转换为电信号，并由大脑转化为被调查对象的心理表征。这种从感觉到感知的转变被认为是哺乳动物皮层的主要功能。在小鼠初级体感觉皮层（S1）中，第5层（L5）锥体神经元是影响感知、决策和运动控制的下游区域的主要输出。我们利用光遗传学鉴定的兴奋性神经元的细胞旁松封贴片记录来研究S1 L5的自我运动和触觉表征。我们发现，在有节奏的胡须运动中，115个活跃神经元中有54个（47%）代表自我运动。该种群受须角的调制明显大于受相位的调制。在主动触摸时，一种独特的活动模式在L5上被唤起，L5代表触摸时的须角。从随机取样的少量这些神经元的触摸诱发的尖峰计数中，物体的位置可以以亚毫米的精度解码。在自我运动和触摸过程中，这些髯须角度的表征在选择哪些神经元是活跃的和在协同活动神经元的角度调节偏好中是独立的。因此，在主动触摸期间，S1的输出瞬间从自我运动的表示转变为探索对象位置的独立表示。熟练地与物体互动需要知道物体相对于自己的位置。这项对老鼠振动系统的研究表明，在触摸过程中，初级体感皮层的输出从自我运动的表征转变为被触摸物体的位置。
During active tactile exploration, the dynamic patterns of touch are transduced to electrical signals and transformed by the brain into a mental representation of the object under investigation. This transformation from sensation to perception is thought to be a major function of the mammalian cortex. In primary somatosensory cortex (S1) of mice, layer 5 (L5) pyramidal neurons are major outputs to downstream areas that influence perception, decision-making, and motor control. We investigated self-motion and touch representations in L5 of S1 with juxtacellular loose-seal patch recordings of optogenetically identified excitatory neurons. We found that during rhythmic whisker movement, 54 of 115 active neurons (47%) represented self-motion. This population was significantly more modulated by whisker angle than by phase. Upon active touch, a distinct pattern of activity was evoked across L5, which represented the whisker angle at the time of touch. Object location was decodable with submillimeter precision from the touch-evoked spike counts of a randomly sampled handful of these neurons. These representations of whisker angle during self-motion and touch were independent, both in the selection of which neurons were active and in the angle-tuning preference of coactive neurons. Thus, the output of S1 transiently shifts from a representation of self-motion to an independent representation of explored object location during active touch. Skillful interactions with objects require knowledge of object location relative to self. This study of the mouse vibrissal system shows that during touch, primary somatosensory cortex output shifts from a representation of self-motion to the location of touched objects.
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影响因子：
16.2
作者：
Hill DN;Curtis JC;Moore JD;Kleinfeld D
通讯作者：
Kleinfeld D
影响因子：
6.4
作者：
FRANCIS, BA;WONHAM, WM
通讯作者：
WONHAM, WM
影响因子：
2.5
作者：
Hires, Samuel Andrew;Schuyler, Adam;Golomb, David
通讯作者：
Golomb, David
影响因子：
9.2
作者：
Furuta, Takahiro;Bush, Nicholas E.;Yang, Anne En-Tzu;Ebara, Satomi;Miyazaki, Naoyuki;Murata, Kazuyoshi;Hirai, Daichi;Shibata, Ken-ichi;Hartmann, Mitra J. Z.
通讯作者：
Hartmann, Mitra J. Z.
影响因子：
2.5
作者：
Fee, MS;Mitra, PP;Kleinfeld, D
通讯作者：
Kleinfeld, D