The independence of and associations among apoptosis, autophagy, and necrosis.
The independence of and associations among apoptosis, autophagy, and necrosis.
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细胞凋亡、自噬和坏死之间的独立性和关联性
DOI：
10.1038/s41392-018-0018-5
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发表时间：
2018
影响因子：
39.3
通讯作者：
Fu C
中科院分区：
文献类型：
--
作者：
Chen Q;Kang J;Fu C
细胞死亡是生理生长发育所必需的生物学过程。细胞死亡的三种经典形式--凋亡、自噬和坏死--通过激活特定的信号通路显示出不同的形态特征。随着最近的研究进展，我们开始意识到这些细胞死亡过程可以通过相互连接甚至重叠的信号通路而相互作用，最终的细胞命运是不同细胞死亡程序相互作用的结果。这篇综述对这三种类型的细胞死亡的独立性和相关性进行了深入的探讨，并探讨了在人类疾病，特别是神经退行性疾病和癌症的特定条件下，细胞死亡的意义。对细胞死亡途径相互联系的新理解可能为癌症和阿尔茨海默氏症等神经退行性疾病提供新的治疗靶点。中国所在的浙江科技大学的傅才云和他的同事们回顾了不同类型细胞死亡之间的机制和联系的最新研究。细胞凋亡，即“程序性”细胞死亡；“坏死”，即细胞“意外”死亡；以及自噬，即细胞破坏受损的内部细胞器的方式，每一种都有独立的分子机制，也可以同时被激活，在应对压力时并行运行。通过药物靶向这些相互关联的机制，可以治疗阿尔茨海默氏症和帕金森氏症等神经退行性疾病，其中去调节的细胞死亡起主要作用，以及癌症，高度增殖的细胞逃避死亡途径。
Cell death is an essential biological process for physiological growth and development. Three classical forms of cell death—apoptosis, autophagy, and necrosis—display distinct morphological features by activating specific signaling pathways. With recent research advances, we have started to appreciate that these cell death processes can cross-talk through interconnecting, even overlapping, signaling pathways, and the final cell fate is the result of the interplay of different cell death programs. This review provides an insight into the independence of and associations among these three types of cell death and explores the significance of cell death under the specific conditions of human diseases, particularly neurodegenerative diseases and cancer. New understandings of the interconnectivity of cell death pathways could provide novel therapeutic targets for cancer and neurodegenerative diseases like Alzheimer’s. Caiyun Fu of China’s Zhejiang Sci-Tech University and colleagues reviewed the latest research into the mechanisms and connections between the different types of cell death. Apoptosis, ‘programmed’ cell death; necrosis, ‘accidental’ cell death; and autophagy, the means by which cells destroy damaged internal organelles, each has independent molecular mechanisms that can also be simultaneously activated, operating in parallel in response to stress. Targeting these interconnected mechanisms with drugs could treat neurodegenerative diseases like Alzheimer’s and Parkinson’s, in which deregulated cell death plays a major role, and cancer, in which highly proliferating cells escape death pathways.
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