Fasting pyloric diameter and distensibility by functional endoluminal imaging probe in unsedated healthy volunteers.
Fasting pyloric diameter and distensibility by functional endoluminal imaging probe in unsedated healthy volunteers.
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DOI：
10.1111/nmo.14386
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发表时间：
2022-10
影响因子：
3.5
通讯作者：
Camilleri, Michael
中科院分区：
文献类型：
--
作者：
Zheng, Ting;Vosoughi, Kia;Busciglio, Irene;Tebay, Lisa;Burton, Duane;Camilleri, Michael
最近的研究使用功能性腔内成像探头（EndoFLIP®）测量幽门的生理特征。EndoFLIP®有可能选择胃经口内镜肌切开术（G-POEM）的最佳候选人。尚未确定使用EndoFLIP®的幽门的标准值。24名健康志愿者（20-56岁; 15名女性）在禁食8小时后接受了幽门的未经镇静的经口EndoFLIP®测量。在40、50和60 mL球囊扩张下，在5分钟内测量两次幽门直径（DM）、球囊压力和扩张指数（DI）。40、50和60 mL球囊扩张时的幽门DM分别为13.0±2.5、14.3±1.8和17.2±2.0 mm。扩张60 mL组DM显著高于扩张40和50 mL组。40、50和60 mL扩张时的幽门DI分别为10.9±4.8、11.3±5.8和11.1±4.3 mm 2/mm Hg（P=0.86）。线性回归和Bland-Altman图显示，与50 mL扩张下的完整5分钟测量值相比，第二分钟期间的DM和DI分布相似，以及使用50 mL扩张的两次连续测量值之间的DM和DI分布相似。在50 mL球囊扩张时，DM和DI的个体内变异系数（COVintra）分别为13.8%和29.6%，个体间变异系数（COVinter）分别为12.6%和51.3%。使用40 mL球囊扩张获得了相似的再现性。未镇静的EndoFLIP®可用于表征人类空腹幽门直径和扩张性，在40 mL和50 mL扩张和第二分钟期间的数据收集下观察到最佳性能。报告的标准值可作为未来研究的参考值。EndoFLIP®用于表征未镇静的健康志愿者的空腹幽门直径和扩张性。在球囊扩张后2分钟观察到稳定的测量，最佳体积为40- 50 mL。
Recent studies with functional endoluminal imaging probe (EndoFLIP®) measure physiologic characteristics of the pylorus. EndoFLIP® has the potential to select optimal candidates for gastric peroral endoscopic myotomy (G-POEM). Normative values of the pylorus using EndoFLIP® have not been established. 24 healthy volunteers (20–56 years old; 15 females) underwent unsedated, transoral EndoFLIP® measurements of the pylorus after 8 hours of fasting. Measurements of diameter (DM), balloon pressure, and distensibility index (DI) of the pylorus were obtained twice over 5 minutes at 40, 50, and 60mL balloon distensions. Pyloric DM at 40, 50, and 60mL balloon distensions were 13.0±2.5, 14.3±1.8, and 17.2±2.0 mm, respectively. DM with 60mL distension was notably higher than with 40 and 50mL distensions. Pyloric DI at 40, 50, and 60mL distensions were 10.9±4.8, 11.3±5.8, and 11.1±4.3 mm2/mm Hg, respectively (P=0.86). Linear regression and Bland-Altman plots showed similar distribution of the DM and DI during the second minute compared to the full 5-minute measurements at 50mL distension, as well as between two sequential measurements using 50mL distension. With 50mL balloon distension, intraindividual coefficients of variation (COVintra) for DM and DI were 13.8% and 29.6%, respectively and interindividual COV (COVinter) were 12.6% and 51.3%, respectively. Similar reproducibility was obtained with 40mL balloon distension. Unsedated EndoFLIP® can be used to characterize human fasting pyloric diameter and distensibility, with best performance observed with 40mL and 50mL distensions and data collection during the second minute. Normative values reported serve as reference values for future studies. EndoFLIP® was used to characterize fasting pyloric diameter and distensibility in unsedated healthy volunteers. Stable measurements were observed at 2 minutes after balloon distension with optimal volume of 40–50mL.
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影响因子：
2.6
作者：
Conchillo JM;Straathof JWA;Mujagic Z;Brouns JH;Bouvy ND;Keszthelyi D;Masclee AAM
通讯作者：
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影响因子：
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作者：
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影响因子：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
Khashab, Mouen A.
影响因子：
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作者：
Jehangir, Asad;Malik, Zubair;Parkman, Henry P.
通讯作者：
Parkman, Henry P.