Right ventricular dynamics during left ventricular assistance in closed-chest dogs.

Right ventricular dynamics during left ventricular assistance in closed-chest dogs.
复制标题

闭胸犬左心室辅助期间的右心室动力学。

DOI:
10.1016/0003-4975(93)90402-4
复制
发表时间:
1993
期刊:
The Annals of thoracic surgery
影响因子:
--
通讯作者:
Miller,DC
Miller,DC
中科院分区:
--
文献类型:
--
作者:
Moon,MR;Castro,LJ;DeAnda,A;Tomizawa,Y;Daughters2nd,GT;IngelsJr,NB;Miller,DC

文献摘要

参考文献

被引文献

相似文献

为了确定左心室辅助装置(LVAD)支持对右心室(RV)整体收缩力学的影响,在放置LVAD(左心室至股动脉旁路)并将27个钽标记物植入左心室和RV壁后,对8只闭胸、清醒、镇静的犬进行了研究,以计算双心室容积和几何形状。在不同水平的LVAD支持下,记录短暂性腔静脉闭塞期间的双平面电影荧光标记图像和血流动力学参数。使用收缩末期弹性和前负荷可复搏功评估右心室收缩力,并计算将机械能转换为外功的心肌(泵)效率(每搏功/总压力-容积面积)。在完全LVAD支持下,右心室舒张末期容积从60 ± 15增加到62 ± 17 mL(p< 0.002),肺动脉输入阻抗从940 ± 636降低到587 ± 347 dyne · s/cm 5(p< 0.007),右心室和左心室无间隔壁尺寸的测量显示了显著的左室间隔移位(p< 0.0005)。整体RV收缩末期弹性和前负荷可复搏功分别从2.4 ± 1.0降至1.7 ± 0.7 mm Hg/mL(p< 0.004)和14.1 ± 3.3降至12.1 ± 3.9 mm Hg(p< 0.02);然而,RV功率输出和心肌效率没有显着变化(分别为p> 0.74和p> 0.33)。因此,在LVAD支持期间,整体RV收缩性随着右室间隔移位而受损,但通过RV后负荷的减少和RV前负荷的增加来维持RV心肌效率和功率输出。
To determine the effects of left ventricular assist device (LVAD) support on global right ventricular (RV) systolic mechanics, 8 closed-chest, conscious, sedated dogs were studied after placement of an LVAD (left ventricle to femoral artery bypass) and implantation of 27 tantalum markers into the left ventricular and RV walls for computation of biventricular volumes and geometry. Biplane cinefluoroscopic marker images and hemodynamic parameters were recorded during transient vena caval occlusion at various levels of LVAD support. Right ventricular contractility was assessed using end-systolic elastance and preload recruitable stroke work, and the myocardial (pump) efficiency of converting mechanical energy to external work (stroke work/total pressure-volume area) was calculated. With full LVAD support, RV end-diastolic volume increased from 60 ± 15 to 62 ± 17 mL (p< 0.002), pulmonary artery input impedance decreased from 940 ± 636 to 587 ± 347 dyne · s/cm5(p< 0.007), and measurement of RV and left ventricular septal-free wall dimensions demonstrated a significantleftwardseptal shift (p< 0.0005). Global RV end-systolic elastance and preload recruitable stroke work decreased from 2.4 ± 1.0 to 1.7 ± 0.7 mm Hg/mL (p< 0.004) and 14.1 ± 3.3 to 12.1 ± 3.9 mm Hg (p< 0.02), respectively; however, RV power output and myocardial efficiency did not change significantly (p> 0.74 andp> 0.33, respectively). Therefore, during LVAD support, global RV contractility is impaired with leftward septal shifting, but RV myocardiol efficiency and power output are maintained through a decrease in RV afterload and an increase in RV preload.
DOI: --
发表时间: 1990
期刊: The Journal of thoracic and cardiovascular surgery
影响因子: --
作者:
DamianoJr,RJ;Asano,T;Smith,PK;Ferguson,TB;Cox,JL
通讯作者: Cox,JL
双心室衰竭对术后心源性休克患者的重要性。
DOI: 10.1016/s0003-4975(10)62516-7
发表时间: 1985
期刊: The Annals of thoracic surgery
影响因子: --
作者:
D. Pennington;J. Merjavy;M. Swartz;J. Codd;H. Barner;D. Lagunoff;H. Bashiti;G. Kaiser;V. Willman
通讯作者: V. Willman
血流动力学改变对犬右心室室壁运动的影响。
DOI: 10.1152/ajpheart.1979.236.2.h254
发表时间: 1979
期刊: The American journal of physiology
影响因子: --
作者:
W. Santamore;G. D. Meier;A. Bove
通讯作者: A. Bove
DOI: --
发表时间: 1980
期刊: Transactions - American Society for Artificial Internal Organs
影响因子: --
作者:
PaeJr,WE;Rosenberg,G;Donachy,JH;Landis,DL;Phillips,WM;Parr,GV;Prophet,GA;Pierce,WS
通讯作者: Pierce,WS
DOI: 10.1161/01.res.69.1.26
发表时间: 1991
影响因子: 20.1
作者:
Adler,D;Nikolic,S;Sonnenblick,EH;Yellin,EL
通讯作者: Yellin,EL