Right ventricular dynamics during left ventricular assistance in closed-chest dogs.
Right ventricular dynamics during left ventricular assistance in closed-chest dogs.
复制标题
闭胸犬左心室辅助期间的右心室动力学。
DOI:
10.1016/0003-4975(93)90402-4
复制
发表时间:
1993
期刊:
影响因子:
--
通讯作者:
Miller,DC
中科院分区:
文献类型:
--
作者:
Moon,MR;Castro,LJ;DeAnda,A;Tomizawa,Y;Daughters2nd,GT;IngelsJr,NB;Miller,DC
To determine the effects of left ventricular assist device (LVAD) support on global right ventricular (RV) systolic mechanics, 8 closed-chest, conscious, sedated dogs were studied after placement of an LVAD (left ventricle to femoral artery bypass) and implantation of 27 tantalum markers into the left ventricular and RV walls for computation of biventricular volumes and geometry. Biplane cinefluoroscopic marker images and hemodynamic parameters were recorded during transient vena caval occlusion at various levels of LVAD support. Right ventricular contractility was assessed using end-systolic elastance and preload recruitable stroke work, and the myocardial (pump) efficiency of converting mechanical energy to external work (stroke work/total pressure-volume area) was calculated. With full LVAD support, RV end-diastolic volume increased from 60 ± 15 to 62 ± 17 mL (p< 0.002), pulmonary artery input impedance decreased from 940 ± 636 to 587 ± 347 dyne · s/cm5(p< 0.007), and measurement of RV and left ventricular septal-free wall dimensions demonstrated a significantleftwardseptal shift (p< 0.0005). Global RV end-systolic elastance and preload recruitable stroke work decreased from 2.4 ± 1.0 to 1.7 ± 0.7 mm Hg/mL (p< 0.004) and 14.1 ± 3.3 to 12.1 ± 3.9 mm Hg (p< 0.02), respectively; however, RV power output and myocardial efficiency did not change significantly (p> 0.74 andp> 0.33, respectively). Therefore, during LVAD support, global RV contractility is impaired with leftward septal shifting, but RV myocardiol efficiency and power output are maintained through a decrease in RV afterload and an increase in RV preload.
登录
查看更多内容
DOI:
--
发表时间:
1990
期刊:
The Journal of thoracic and cardiovascular surgery
影响因子:
--
作者:
DamianoJr,RJ;Asano,T;Smith,PK;Ferguson,TB;Cox,JL
通讯作者:
Cox,JL
DOI:
10.1016/s0003-4975(10)62516-7
发表时间:
1985
期刊:
The Annals of thoracic surgery
影响因子:
--
作者:
D. Pennington;J. Merjavy;M. Swartz;J. Codd;H. Barner;D. Lagunoff;H. Bashiti;G. Kaiser;V. Willman
通讯作者:
V. Willman
DOI:
10.1152/ajpheart.1979.236.2.h254
发表时间:
1979
期刊:
The American journal of physiology
影响因子:
--
作者:
W. Santamore;G. D. Meier;A. Bove
通讯作者:
A. Bove
DOI:
--
发表时间:
1980
期刊:
Transactions - American Society for Artificial Internal Organs
影响因子:
--
作者:
PaeJr,WE;Rosenberg,G;Donachy,JH;Landis,DL;Phillips,WM;Parr,GV;Prophet,GA;Pierce,WS
通讯作者:
Pierce,WS
影响因子:
20.1
作者:
Adler,D;Nikolic,S;Sonnenblick,EH;Yellin,EL
通讯作者:
Yellin,EL