Cellular and Molecular Progression of Prostate Cancer: Models for Basic and Preclinical Research.
Cellular and Molecular Progression of Prostate Cancer: Models for Basic and Preclinical Research.
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DOI：
10.3390/cancers12092651
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发表时间：
2020-09-17
期刊：
影响因子：
5.2
通讯作者：
Singh AP
中科院分区：
文献类型：
--
作者：
Saranyutanon S;Deshmukh SK;Dasgupta S;Pai S;Singh S;Singh AP
前列腺癌的分子进展是复杂和难以捉摸的。生物学研究在很大程度上依赖于体外和体内模型，这些模型可用于在实验室和临床前环境中检查基因功能和对外部试剂的反应。多年来，已经开发了几种模型，发现它们对了解前列腺癌的生物学非常有帮助。在这里，我们描述了这些模型的背景下，前列腺癌的细胞和分子进展的可用信息，以表明其在基础和临床前前列腺癌研究的潜在效用。本文讨论的信息应该作为从事前列腺癌研究的学者或那些正在过渡到探索前列腺癌复杂生物学的人的实践资源。在过去的几十年里，我们在对前列腺癌的认识方面取得了显著的进展。这些基本知识已转化为有效的诊断和治疗方法，从而提高患者的生存率。然而，前列腺癌的分子发病机制似乎是复杂的，组织学检查结果往往不能提供一个准确的评估疾病的侵略性和未来的过程。此外，我们还见证了前列腺癌发病率和临床结果的巨大种族差异，需要更深入地了解前列腺癌的分子和机制基础。生物学研究严重依赖于模型系统，这些模型系统可以在受控的实验环境下容易地操作和测试。多年来，已经开发了代表前列腺癌的不同分子亚型的几种癌细胞系。此外，已经开发了几种动物模型来证明前列腺癌的病因学分子基础。近年来，患者来源的异种移植物和3-D培养模型也被创建并用于临床前研究。这篇综述试图简明扼要地讨论前列腺癌细胞和分子进展的现有信息。我们还讨论了可用的模型系统和它们在基础和临床前前列腺癌研究中的测试和潜在效用。
The molecular progression of prostate cancer is complex and elusive. Biological research relies heavily on in vitro and in vivo models that can be used to examine gene functions and responses to the external agents in laboratory and preclinical settings. Over the years, several models have been developed and found to be very helpful in understanding the biology of prostate cancer. Here we describe these models in the context of available information on the cellular and molecular progression of prostate cancer to suggest their potential utility in basic and preclinical prostate cancer research. The information discussed herein should serve as a hands-on resource for scholars engaged in prostate cancer research or to those who are making a transition to explore the complex biology of prostate cancer. We have witnessed noteworthy progress in our understanding of prostate cancer over the past decades. This basic knowledge has been translated into efficient diagnostic and treatment approaches leading to the improvement in patient survival. However, the molecular pathogenesis of prostate cancer appears to be complex, and histological findings often do not provide an accurate assessment of disease aggressiveness and future course. Moreover, we also witness tremendous racial disparity in prostate cancer incidence and clinical outcomes necessitating a deeper understanding of molecular and mechanistic bases of prostate cancer. Biological research heavily relies on model systems that can be easily manipulated and tested under a controlled experimental environment. Over the years, several cancer cell lines have been developed representing diverse molecular subtypes of prostate cancer. In addition, several animal models have been developed to demonstrate the etiological molecular basis of the prostate cancer. In recent years, patient-derived xenograft and 3-D culture models have also been created and utilized in preclinical research. This review is an attempt to succinctly discuss existing information on the cellular and molecular progression of prostate cancer. We also discuss available model systems and their tested and potential utility in basic and preclinical prostate cancer research.
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DOI：
10.1042/bj20111741
发表时间：
2012-02-15
期刊：
The Biochemical journal
影响因子：
--
作者：
Berenjeno IM;Guillermet-Guibert J;Pearce W;Gray A;Fleming S;Vanhaesebroeck B
通讯作者：
Vanhaesebroeck B
影响因子：
5.9
作者：
Annala M;Taavitsainen S;Vandekerkhove G;Bacon JVW;Beja K;Chi KN;Nykter M;Wyatt AW
通讯作者：
Wyatt AW
影响因子：
11.5
作者：
Chen, William S.;Alshalalfa, Mohammed;Feng, Felix Y.
通讯作者：
Feng, Felix Y.
影响因子：
2.8
作者：
Corey, E;Quinn, JE;Vessella, RL
通讯作者：
Vessella, RL
影响因子：
82.9
作者：
Craft, N;Shostak, Y;Sawyers, CL
通讯作者：
Sawyers, CL