Assessment of reward responsiveness in the response bias probabilistic reward task in rats: implications for cross-species translational research.
Assessment of reward responsiveness in the response bias probabilistic reward task in rats: implications for cross-species translational research.
复制标题
DOI：
10.1038/tp.2013.74
复制
发表时间：
2013-08-27
影响因子：
6.8
通讯作者：
Markou A
中科院分区：
文献类型：
--
作者：
Der-Avakian A;D'Souza MS;Pizzagalli DA;Markou A
情绪障碍，如重度抑郁症，以异常的奖励反应为特征。反应偏差概率奖励任务（下文称为概率奖励任务（PRT））量化了人类受试者的奖励反应，需要进行等效的动物评估以促进临床前转化研究。因此，本研究的目标是开发、验证和表征PRT的大鼠类似物。成年雄性Wistar和Long-Evans大鼠在操作性测试箱中进行训练，以区分持续时间不同（0.5和2秒）的两种音调刺激。在随后的100次试验中，这两个音调变得模糊（0.9和1.6秒），一个音调的正确识别是用比另一个音调更频繁三倍的食物颗粒来加强的。在随后的实验中，Wistar大鼠在试验前给予低剂量的多巴胺D2/D3受体激动剂普拉克索（0.1 mg kg−1，皮下）或精神兴奋剂安非他明（0.5 mg kg−1，腹膜内）。与人类受试者相似，两种大鼠品系都对更频繁强化的刺激产生了反应偏好，反映了强大的奖励反应。与先前在人体中的发现相似，低剂量的普拉克索减弱了反应偏倚。此外，在大鼠中，安非他明增强反应偏差。这些结果表明，在大鼠中，奖赏反应可以量化和双向调制的药理学操作，改变纹状体多巴胺的传输。因此，这种在大鼠中的新程序在概念上和程序上类似于在人类中使用的程序，提供了一个反向翻译平台来研究跨物种的异常奖励反应。
Mood disorders, such as major depressive disorder, are characterized by abnormal reward responsiveness. The Response Bias Probabilistic Reward Task (hereafter referred to as probabilistic reward task (PRT)) quantifies reward responsiveness in human subjects, and an equivalent animal assessment is needed to facilitate preclinical translational research. Thus, the goals of the present studies were to develop, validate and characterize a rat analog of the PRT. Adult male Wistar and Long–Evans rats were trained in operant testing chambers to discriminate between two tone stimuli that varied in duration (0.5 and 2 s). During a subsequent test session consisting of 100 trials, the two tones were made ambiguous (0.9 and 1.6 s) and correct identification of one tone was reinforced with a food pellet three times more frequently than the other tone. In subsequent experiments, Wistar rats were administered either a low dose of the dopamine D2/D3 receptor agonist pramipexole (0.1 mg kg−1, subcutaneous) or the psychostimulant amphetamine (0.5 mg kg−1, intraperitoneal) before the test session. Similar to human subjects, both rat strains developed a response bias toward the more frequently reinforced stimulus, reflecting robust reward responsiveness. Mirroring prior findings in humans, a low dose of pramipexole blunted response bias. Moreover, in rats, amphetamine potentiated response bias. These results indicate that in rats, reward responsiveness can be quantified and bidirectionally modulated by pharmacological manipulations that alter striatal dopamine transmission. Thus, this new procedure in rats, which is conceptually and procedurally analogous to the one used in humans, provides a reverse translational platform to investigate abnormal reward responsiveness across species.
登录
查看更多内容
影响因子：
15.9
作者：
Der-Avakian A;Markou A
通讯作者：
Markou A
DOI：
10.1073/pnas.1014269108
发表时间：
2011-09-13
影响因子：
11.1
作者：
Glimcher, Paul W.
通讯作者：
Glimcher, Paul W.
影响因子：
25
作者：
Maia, Tiago V.;Frank, Michael J.
通讯作者：
Frank, Michael J.
影响因子：
--
作者：
Lambert, G;Johansson, M;Friberg, P
通讯作者：
Friberg, P
影响因子：
7.6
作者：
Enkel, Thomas;Gholizadeh, Donya;Vollmayr, Barbara
通讯作者：
Vollmayr, Barbara