The neurobiology of anhedonia and other reward-related deficits.
The neurobiology of anhedonia and other reward-related deficits.
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DOI：
10.1016/j.tins.2011.11.005
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发表时间：
2012-01
影响因子：
15.9
通讯作者：
Markou A
中科院分区：
文献类型：
--
作者：
Der-Avakian A;Markou A
快感缺乏，或明显减少的兴趣或快乐，是严重抑郁症，精神分裂症和其他神经精神疾病的标志性症状。在过去的30年里，尽管认知心理学和行为神经科学扩展了我们对其他奖励相关过程的理解，但快感缺失的临床定义相对保持不变。在这里，我们回顾了快感缺乏的神经基础，它反映了享乐能力的缺陷，也与奖励评估，决策，预期和动机的结构密切相关。支持这些奖赏相关过程的神经回路包括腹侧纹状体、前额叶皮质区以及传入和传出投射。了解快感缺乏和其他奖励相关的结构将有助于诊断和治疗包括奖励缺陷作为关键症状的疾病。
Anhedonia, or markedly diminished interest or pleasure, is a hallmark symptom of major depression, schizophrenia, and other neuropsychiatric disorders. Over the past three decades, the clinical definition of anhedonia has remained relatively unchanged, although cognitive psychology and behavioral neuroscience have expanded our understanding of other reward-related processes. Here, we review the neural bases of the construct of anhedonia that reflects deficits in hedonic capacity, and is also closely linked to the constructs of reward valuation, decision-making, anticipation, and motivation. The neural circuits subserving these reward-related processes include the ventral striatum, prefrontal cortical regions, and afferent and efferent projections. Understanding anhedonia and other reward-related constructs will facilitate diagnosis and treatment of disorders that include reward deficits as key symptoms.
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影响因子：
10.6
作者：
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通讯作者：
Barch, Deanna M.
影响因子：
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