Association of Dysplastic Coronoid Process with Long-Face Morphology
Association of Dysplastic Coronoid Process with Long-Face Morphology
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发育不良的冠状突与长脸形态的关联
DOI：
10.1177/0022034519892551
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发表时间：
2019-12
影响因子：
7.6
通讯作者：
Chen Y. P.
中科院分区：
文献类型：
--
作者：
Chen T.;Liu Z.;Xue C.;Tian W.;Bai D.;Chen Y. P.
垂直性错牙合是一种发育性疾病，是生长发育过程中多种病因相互作用的结果。长脸（LF）形态是临床上一种棘手的牙面畸形，其特征是面部过度垂直生长，颌骨和牙齿严重排列混乱。由于LF患者的面部轮廓和咬合的改善往往是困难的，缺乏长期的稳定性，因此，阐明LF模式形成的病因以早期预防和治疗变得重要。在目前的研究中，我们确定了一个转基因小鼠模型，表现出发育不良的冠状突和LF形态。虽然突变小鼠在出生时表现出与对照组相当的颌骨结构和咬合，但它们在出生后生长期间均获得了典型的LF形态，前开咬，类似于所选骨骼III类患者的临床特征。由于冠状突为颞肌附着提供了一个插入位点，我们研究了颞肌的初始发育和分化，发现在E17.5之前，颞肌附着到冠状突时，对照组和突变组小鼠的结果相同。然而，此后，我们观察到改变的方向和减少大小的横截面积的颞肌突变小鼠，持续到断奶阶段。生物力学分析和模拟建模进一步支持的想法，改变形态的冠状突可能会损害垂直颞肌收缩的效率，并出现与LF的形成。因此，我们提出的证据表明，发育不良的下颌冠状突也被认为是在一些人类患者的骨骼III LF形态。综上所述，本研究的结果建立了颅面骨结构与垂直模式的关联，这将对临床预防和干预的早期预测产生影响。
Vertical malocclusion is a developmental condition, resulting from complex interactions among multiple etiological factors during the growth period. As a tricky dentofacial deformity clinically, long-face (LF) morphology is characterized by excessive vertical facial growth with severe disarrangement of jaws and teeth. Since the improvement of LF patients on facial profile and occlusion is often difficult and lacks long-term stability, it becomes important to unravel the etiology of LF pattern formation for early prevention and treatment. In the current studies, we identified a transgenic mouse model that exhibited a dysplastic coronoid process and LF morphology. Although the mutant mice exhibited jaw structures and occlusion comparable to controls at birth, they all acquired typical LF morphology with anterior open bite during postnatal growth, resembling clinical features of the selected skeletal class III patients. Since the coronoid process provides an insertion site for the temporalis attachment, we examined the initial development and differentiation of the temporalis and found identical results in both control and mutant mice before E17.5 when the temporal muscle makes attachment to the coronoid process. However, thereafter, we observed altered orientation and reduced size of the cross-sectional area of the temporalis in mutant mice, which persisted to the weaning stage. Biomechanical analysis and simulation modeling further support the idea that altered morphology of the coronoid process may impair the efficiency of the vertical temporalis contraction and appears to correlate with LF formation. Consistently, we present evidence that a dysplastic mandibular coronoid process was also seen in some human patients with skeletal III LF morphology. Taken together, the results presented in this study establish an association of the craniofacial bony structures with vertical patterning, which will have implications in earlier prediction for clinical precaution and intervention.
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影响因子：
2.1
作者：
C. Dreyer;M. Woods
通讯作者：
C. Dreyer;M. Woods
影响因子：
2.6
作者：
Benington, PCM;Gardener, JE;Hunt, NP
通讯作者：
Hunt, NP
影响因子：
7.6
作者：
PROFFIT, WR;FIELDS, HW
通讯作者：
FIELDS, HW
DOI：
--
发表时间：
--
期刊：
--
影响因子：
--
作者：
Wenduo Ye;Yingnan Song;Zhen Huang;Yanding Zhang;Yiping Chen;R. Poelmann;M. Jongbloed
通讯作者：
Wenduo Ye;Yingnan Song;Zhen Huang;Yanding Zhang;Yiping Chen;R. Poelmann;M. Jongbloed
影响因子：
7.6
作者：
P. van Spronsen;W. Weijs;EC van Ginkel;B. Prahl-Andersen
通讯作者：
P. van Spronsen;W. Weijs;EC van Ginkel;B. Prahl-Andersen