Survey on retinopathy of prematurity (ROP) in Italy.
Survey on retinopathy of prematurity (ROP) in Italy.
复制标题
DOI：
10.1186/1824-7288-39-43
复制
发表时间：
2013-07-09
影响因子：
3.6
通讯作者：
Italian ROP study group
中科院分区：
文献类型：
--
作者：
Borroni C;Carlevaro C;Morzenti S;De Ponti E;Bozzetti V;Console V;Capobianco S;Tagliabue PE;Italian ROP study group
本研究旨在调查早产儿视网膜病变（ROP）和后视网膜病变（P-ROP）的发病率和相关危险因素：I区和后II区的ROP，以及分析ROP手术治疗的发生率和评价意大利该病的短期结局。这是一项前瞻性多中心观察性研究; 2008年1月1日至2009年12月31日期间在25个III级意大利新生儿重症监护病房出生的所有出生体重（BW）≤ 750 g和/或胎龄（GA）≤27周的婴儿均符合研究资格。共检查421例婴儿，其中ROP 265例（62.9%），P-ROP 102例（24.2%）。多变量分析后，促红细胞生成素治疗（p < 0.0001）和脑室内出血（IVH）（p = 0.003）与ROP显著相关，而胎龄≤24周（p = 0.011）和脓毒症（p = 0.002）与P-ROP的发生相关。89名婴儿（34%）需要手术治疗;多变量分析后，P-ROP是与手术治疗需求相关的独立因素（p < 0.0001）。据报道，251例（94.7%）受ROP影响的新生儿结局良好。14例患者发生不良结局：所有患者均接受手术并显示P-ROP。P-ROP是ROP中最具侵略性的类型。它与低GA和败血症有关。产科医生和新生儿医生必须专注于减少严重早产和预防新生儿早发型和晚发型败血症，以降低P-ROP的发病率。
This study aims to investigate the incidence and the relative risk factors of retinopathy of prematurity (ROP) and posterior-ROP (P-ROP): ROP in Zone I and posterior Zone II, as well as to analyze the occurrence of surgical treatment of ROP and to evaluate the short term outcome of the disease in Italy. It is a prospective multicenter observational study; all infants with a birth weight (BW) ≤ 750 g and/or a gestational age (GA) ≤27 weeks born between January 1st 2008 and December 31st 2009 in 25 III level Italian neonatal intensive care units were eligible for the study. 421 infants were examined: 265 (62.9%) developed ROP and 102 (24.2%) P-ROP. Following the multivariate analysis erythropoietin-therapy (p < 0.0001) and intraventricular hemorrhage (IVH) (p = 0.003) were significantly associated with ROP while gestational age ≤24 weeks (p = 0.011) and sepsis (p = 0.002) were associated with the onset of P-ROP. Eighty nine infants (34%) required surgical treatment; following the multivariate analysis P-ROP was an independent factor associated with the need of surgical treatment (p < 0.0001). A favorable outcome was reported in 251 (94.7%) newborns affected by ROP. Adverse outcome occurred in 14 patients: all of them underwent surgery and showed P-ROP. P-ROP is the most aggressive type of ROP. It associates with lower GA and sepsis. Obstetricians and Neonatologists must focus on the reduction of severe preterm births and on the prevention of neonatal early and late onset sepsis in order to reduce the incidence of P-ROP.
登录
查看更多内容
影响因子：
8
作者：
Chen ML;Guo L;Smith LE;Dammann CE;Dammann O
通讯作者：
Dammann O
影响因子：
9.8
作者：
Chen, Jing;Smith, Lois E. H.
通讯作者：
Smith, Lois E. H.
影响因子：
8
作者：
Lichtenstein, SJ;Buckley, EG;Saunders, R
通讯作者：
Saunders, R
影响因子：
158.5
作者：
FLYNN, JT;BANCALARI, E;GILLINGS, D
通讯作者：
GILLINGS, D
影响因子：
4
作者：
Darlow, Brian A.;Elder, Mark J.;Henderson-Smart, David J.
通讯作者：
Henderson-Smart, David J.