High or low oxygen saturation and severe retinopathy of prematurity: a meta-analysis.
High or low oxygen saturation and severe retinopathy of prematurity: a meta-analysis.
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DOI：
10.1542/peds.2009-2218
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发表时间：
2010-06
期刊：
影响因子：
8
通讯作者：
Dammann O
中科院分区：
文献类型：
--
作者：
Chen ML;Guo L;Smith LE;Dammann CE;Dammann O
在出生后的前几周内给予低氧饱和度似乎可以降低早产儿严重早产儿视网膜病变（ROP）的风险。高血氧饱和度似乎可以降低月经后期年龄（PMA）的风险。然而，以前的临床研究并没有单独得出结论。进行系统性综述和荟萃分析，以报告早产儿重度ROP发生率与脉搏血氧饱和度测量的高或低目标血氧饱和度之间的相关性。通过PubMed和Embase文献检索，使用术语“早产儿视网膜病变和氧疗”或“早产儿视网膜病变和氧疗”，确定了截至2009年5月的研究。我们选择了10篇发表文章，阐述了严重ROP与通过脉搏血氧仪测量的目标氧饱和度之间的关联。使用随机效应模型，我们计算了汇总效应估计值。我们目视检查漏斗图，以检查可能的发表偏倚。出生后前几周的低氧饱和度（70%-96%）与严重ROP的风险降低相关（风险比[RR]：0.48 [95%置信区间（CI）：0.31-0.75]）。PMA ≥32周时的高血氧饱和度（94%-99%）与进展为重度ROP的风险降低相关（RR：0.54 [95% CI：0.35-0.82]）。在胎龄≤32周的早产儿中，早期低血氧饱和度和晚期高血氧饱和度与严重ROP的风险降低相关。我们认为，一个大型的随机临床试验，长期的发展随访是必要的，以确认这一荟萃分析结果。
Low oxygen saturation appears to decrease the risk of severe retinopathy of prematurity (ROP) in preterm newborns when administered during the first few weeks after birth. High oxygen saturation seems to reduce the risk at later postmenstrual ages (PMAs). However, previous clinical studies are not conclusive individually. To perform a systematic review and meta-analysis to report the association between severe ROP incidence of premature infants with high or low target oxygen saturation measured by pulse oximetry. Studies were identified through PubMed and Embase literature searches through May 2009 by using the terms “retinopathy of prematurity and oxygen” or “retinopathy of prematurity and oxygen therapy.” We selected 10 publications addressing the association between severe ROP and target oxygen saturation measured by pulse oximetry. Using a random-effects model we calculated the summary-effect estimate. We visually inspected funnel plots to examine possible publication bias. Low oxygen saturation (70%–96%) in the first several postnatal weeks was associated with a reduced risk of severe ROP (risk ratio [RR]: 0.48 [95% confidence interval (CI): 0.31–0.75]). High oxygen saturation (94%–99%) at ≥32 weeks’ PMA was associated with a decreased risk for progression to severe ROP (RR: 0.54 [95% CI: 0.35–0.82]). Among preterm infants with a gestational age of ≤32 weeks, early low and late high oxygen saturation were associated with a reduced risk for severe ROP. We feel that a large randomized clinical trial with long-term developmental follow-up is warranted to confirm this meta-analytic result.
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影响因子：
9.8
作者：
Chen, Jing;Smith, Lois E. H.
通讯作者：
Smith, Lois E. H.
DOI：
10.1038/sj.jp.7210740
发表时间：
2002-07-01
期刊：
Journal of perinatology : official journal of the California Perinatal Association
影响因子：
--
作者：
Hay, William W Jr;Rodden, Donna J;Fashaw, Lucy M
通讯作者：
Fashaw, Lucy M
影响因子：
158.5
作者：
FLYNN, JT;BANCALARI, E;GILLINGS, D
通讯作者：
GILLINGS, D
影响因子：
8
作者：
Good, WV
通讯作者：
Good, WV
影响因子：
4.2
作者：
ADAMIS, AP;MILLER, JW;YEO, KT
通讯作者：
YEO, KT