p53 induction prevents accumulation of aberrant transcripts in cancer cells.
p53 induction prevents accumulation of aberrant transcripts in cancer cells.
复制标题
p53 诱导可防止癌细胞中异常转录物的积累。
作者：
C. Moyret;C. Duriez;J. Van Kerckhove;C. Gilbert;Q. Wang;A. Puisieux
剪接过程保真度的丧失发生在肿瘤进展过程中，并可能对肿瘤抑制基因等基因产生有害影响。最近有报道称，乳腺癌细胞中TSG101基因异常转录本的存在与p53肿瘤抑制基因突变有关。在此基础上，我们分析了TSG101在p53活性细胞和p53非活性细胞中的转录模式。使用几个等基因细胞模型，我们证明在癌细胞中诱导p53导致异常转录物水平显著降低。这表明p53在剪接过程的调控中具有新的含义。
Loss of fidelity of the splicing process occurs during tumor progression and can have a deleterious effect on genes like tumor suppressor genes. It was reported recently that the presence of aberrant transcripts of the TSG101 gene in breast cancer cells was associated with the mutation of the p53 tumor suppressor gene. On the basis of this observation, we have analyzed TSG101 transcript patterns in p53-active and p53-inactive cells. Using several isogenic cellular models, we demonstrate that the induction of p53 in cancer cells leads to a significant decrease of aberrant transcripts levels. This indicates a novel implication of p53 in the regulation of the splicing process.
影响因子：
56.9
作者：
Bunz, F;Dutriaux, A;Vogelstein, B
通讯作者：
Vogelstein, B
影响因子：
8
作者：
S. Bacus;Y. Yarden;M. Oren;D. Chin;L. Lyass;C. Zelnick;A. Kazarov;W. Toyofuku;J. Gray-Bablin;R. Beerli;N. Hynes;M. Nikiforov;R. Haffner;A. Gudkov;K. Keyomarsi
通讯作者：
S. Bacus;Y. Yarden;M. Oren;D. Chin;L. Lyass;C. Zelnick;A. Kazarov;W. Toyofuku;J. Gray-Bablin;R. Beerli;N. Hynes;M. Nikiforov;R. Haffner;A. Gudkov;K. Keyomarsi