Biochemical Pharmacology of Alcohol
Biochemical Pharmacology of Alcohol
复制标题
酒精的生化药理学
DOI：
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发表时间：
1982
期刊：
影响因子：
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通讯作者：
J. Mendelson
中科院分区：
文献类型：
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作者：
J. Ellingboe;J. Mendelson
近年来，已经获得了大量的数据来描述醇对生物系统的作用的多样性。虽然对阿片药物的研究导致了内源性阿片肽和介导其作用的特定受体的发现，但对酒精的研究揭示了日益复杂的主要作用和多种继发性生物学后果。与鸦片类生物碱和内源性多肽相比，乙醇缺乏信息含量。它更简单的分子结构不太可能与特定的假定受体特异性地相互作用。由于其物理和化学性质，乙醇可以被认为对生物系统具有双重作用。像其他非特异性麻醉剂一样，它产生一些效果是因为它与生物膜的极性和非极性相互作用的特殊平衡。乙醇的另一个重要特性是它是一种可氧化的底物，具有多种后果，包括扰乱正常代谢和产生高活性和潜在毒性的物质乙醛。
During recent years, a large amount of data has been obtained describing the diversity of alcohol actions on biologic systems. While the study of opiate drugs has led to the discovery of endogenous opioid peptides and specific receptors mediating their actions, investigations of alcohol have revealed increasingly complex primary effects and a multitude of secondary biologic consequences. In contrast to opiate alkaloids and endogenous peptides, ethanol is lacking in informational content. Its much simpler molecular structure is less likely to be able to interact specifically with a particular putative receptor. Because of its physical and chemical properties, ethanol can be considered to have dual actions on biologic systems. Like other nonspecific anesthetics, it produces some of its effects because of its particular balance of polar and nonpolar interactions with biologic membranes. The other important property of ethanol is that of an oxidizable substrate, with multiple consequences that include perturbation of normal metabolism and the production of the highly reactive and potentially toxic agent, acetaldehyde.
DOI：
10.1111/j.1530-0277.1984.tb05682.x
发表时间：
1984
期刊：
Alcoholism, clinical and experimental research
影响因子：
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作者：
Wilson,JR;Erwin,VG;McClearn,GE;Plomin,R;Johnson,RC;Ahern,FM;Cole,RE
通讯作者：
Cole,RE