First use of (18)F-labeled ML-10 PET to assess apoptosis change in a newly diagnosed glioblastoma multiforme patient before and early after therapy.
First use of (18)F-labeled ML-10 PET to assess apoptosis change in a newly diagnosed glioblastoma multiforme patient before and early after therapy.
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DOI：
10.1002/brb3.217
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发表时间：
2014-03
影响因子：
3.1
通讯作者：
Mountz, James M.
中科院分区：
文献类型：
--
作者：
Oborski, Matthew J.;Laymon, Charles M.;Lieberman, Frank S.;Drappatz, Jan;Hamilton, Ronald L.;Mountz, James M.
作者首次使用新型正电子发射断层扫描 (PET) 细胞凋亡示踪剂 18F 标记的 2-(5-氟戊基)-2-甲基-丙二酸 (18F-ML-10) 对新诊断的多形性胶质母细胞瘤 (GBM) 患者进行早期治疗反应评估。一名新诊断为 GBM 的 71 岁男性在开始治疗前（基线）以及完成 3 周全脑放射治疗并伴随替莫唑胺化疗后接受 18F-ML-10 PET 扫描（早期治疗评估，ETA）。基线 18F-ML-10 PET 扫描显示 GBM 部位示踪剂摄取增加，其中肿瘤中心部分的活性最高。在预计到达时间点，与基线相比，观察到示踪剂摄取的新分布。使用从ETA减去基线的标准化逐像素减去来量化18F-ML-10 PET成像时间点之间示踪剂分布的变化。该分析结果显示，在最大基线摄取部位，18F-ML-10 摄取减少，但在早期治疗时间点，肿瘤周边周围的摄取增加。基线和预计到达时间之间 18F-ML-10 摄取的变化模式提示治疗诱导的肿瘤细胞凋亡。
The authors present the first use of the novel positron emission tomography (PET) apoptosis tracer 18F-labeled 2-(5-fluoro-pentyl)-2-methyl-malonic acid (18F-ML-10) for early-therapy response assessment of a newly diagnosed glioblastoma multiforme (GBM) patient. A 71-year-old male with a newly diagnosed GBM received 18F-ML-10 PET scans prior to therapy initiation (baseline) and after completing 3 weeks of whole-brain radiation therapy with concomitant temozolomide chemotherapy (early-therapy assessment, ETA). The baseline 18F-ML-10 PET scan showed increased tracer uptake at the site of the GBM, with highest activity toward the central portion of the tumor. At the ETA time point, a new distribution of tracer uptake was observed compared to baseline. Normalized pixel-by-pixel subtraction of baseline from ETA was used to quantify change in tracer distribution between 18F-ML-10 PET imaging time points. Results of this analysis showed reduction in 18F-ML-10 uptake at the site of greatest baseline uptake, but increased uptake around the periphery of the tumor at the early-therapy time point. The changing patterns of 18F-ML-10 uptake between baseline and ETA are suggestive for therapy-induced tumor cellular apoptosis.
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影响因子：
4.2
作者：
Reshef, Ayelet;Shirvan, Anat;Ziv, Ilan
通讯作者：
Ziv, Ilan
影响因子：
2.9
作者：
Reshef, Ayelet;Shirvan, Anat;Ziv, Ilan
通讯作者：
Ziv, Ilan
影响因子：
3.4
作者：
Fernandez-Luna, J. L.
通讯作者：
Fernandez-Luna, J. L.
影响因子：
1.7
作者：
Witham, TF;Okada, H;Kondziolka, D
通讯作者：
Kondziolka, D
影响因子：
44.1
作者：
Cohen, Avi;Shirvan, Anat;Ziv, Ilan
通讯作者：
Ziv, Ilan