Role of bacterial infections in extracellular vesicles release and impact on immune response.
Role of bacterial infections in extracellular vesicles release and impact on immune response.
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DOI：
10.1016/j.bj.2020.05.006
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发表时间：
2021-04
影响因子：
5.5
通讯作者：
Yeruva L
中科院分区：
文献类型：
--
作者：
Spencer N;Yeruva L
细胞外囊泡（EV）生物学涉及理解细胞通讯的细胞和分子机制。到目前为止，用各种细菌感染模型进行的研究表明，释放了各种类型的EV，包括外来体和微泡。根据感染和细胞类型，EV货物组成发生变化，最终可能影响宿主免疫反应和细菌生长。电动汽车释放背后的机制，货物组成和对免疫系统的影响尚未得到充分研究。未来的研究需要包括体内模型，以了解细菌感染期间EV与宿主免疫功能的相关性，并确定宿主中共享或物种特异性的方面。这将有助于开发EV作为治疗剂或疾病标志物。
Extracellular vesicle (EV) biology involves understanding the cellular and molecular mechanisms of cell communication. Studies conducted so far with various bacterial infection models demonstrate the release of various types of EVs that include exosomes and microvesicles. Depending upon the infection and cell type, EV cargo composition changes and ultimately might impact the host immune response and bacterial growth. The mechanisms behind the EVs release, cargo composition, and impact on the immune system have not been fully investigated. Future research needs to include in vivo models to understand the relevance of EVs in host immune function during bacterial infection, and to determine aspects that are shared or species-specific in the host. This would aid in the development of EVs as therapeutics or as markers of disease.
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影响因子：
7.3
作者：
Andreu Z;Yáñez-Mó M
通讯作者：
Yáñez-Mó M
影响因子：
4.5
作者：
Beatty, WL;Rhoades, ER;Russell, DG
通讯作者：
Russell, DG
影响因子：
4
作者：
Colombo, Marina;Moita, Catarina;Raposo, Graca
通讯作者：
Raposo, Graca
影响因子：
16
作者：
Bobrie A;Colombo M;Krumeich S;Raposo G;Théry C
通讯作者：
Théry C
DOI：
10.1083/jcb.131.6.1435
发表时间：
1995-12
期刊：
The Journal of cell biology
影响因子：
--
作者：
Feng Y;Press B;Wandinger-Ness A
通讯作者：
Wandinger-Ness A